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Biomarkers Volume 18, 2013 - Issue 8
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Research Article

Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer

Qingfan YangInstitute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin NTHong Kong;State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong Shatin, NTHong Kong;Shenzhen Research Institute, The Chinese University of Hong Kong ShenzhenPeople's Republic of China;Department of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University GuangzhouPeople’s Republic of China
,
Jing GaoKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute BeijingPeople’s Republic of China
,
Lixia XuInstitute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin NTHong Kong;State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong Shatin, NTHong Kong;Shenzhen Research Institute, The Chinese University of Hong Kong ShenzhenPeople's Republic of China
,
Zhirong ZengDepartment of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University GuangzhouPeople’s Republic of ChinaCorrespondence[email protected]
[email protected]
,
Joseph J. Y. SungInstitute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin NTHong Kong;State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong Shatin, NTHong Kong;Shenzhen Research Institute, The Chinese University of Hong Kong ShenzhenPeople's Republic of China
&
Jun YuInstitute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin NTHong Kong;State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong Shatin, NTHong Kong;Shenzhen Research Institute, The Chinese University of Hong Kong ShenzhenPeople's Republic of ChinaCorrespondence[email protected]
Pages 721-725 | Received 11 Aug 2013, Accepted 07 Oct 2013, Published online: 06 Nov 2013
 
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Abstract

We previously showed that BCL6B acts as a tumor suppressor in gastric cancer and up to 66% gastric cancer patients have promoter hypermethylation in tumor tissues. We aimed to evaluate the feasibility of detecting BCL6B methylation in plasma DNA as a potential biomarker for gastric cancer. Hypermethylation of the CpG islands in BCL6B promoter was detected in 42.5% (17/40) plasma DNA samples from gastric cancer patients, while no methylation was found in the plasma DNA of healthy controls (p < 0.001). BCL6B methylation may serve as a novel potential non-invasive plasma biomarker for the detection of gastric cancer.

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