Effects of perioperative blood transfusion on the prognosis in hereditary and sporadic colon cancer

Abstract

We investigated the effects of perioperative blood transfusion in the prognosis of hereditary and sporadic colon cancer. There are 1075 colon cancer patients, including 936 sporadic colon cancer and 139 with hereditary colon cancer undergoing surgery at our hospital. All patients underwent 10 years of follow-up. In the sporadic group, mortality, local recurrence rate and distant metastases rate of transfused patients were significantly higher than non-transfused patients. The 10-year survival rates were significantly lower in patients receiving blood transfusions compared to non-transfused patients. In the hereditary group, mortality was higher in transfused patients compared to non-transfused patients.

• Allogeneic red blood cell transfusion
• colon cancer
• hereditary colon cancer
• mortality
• perioperative blood transfusion
• prognosis survival
• sporadic colon cancer

Acknowledgements

We would like to thank our researchers for their hard work and reviewers for their valuable advice.

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper. This study was funded by the Natural Science Fund Project in Liaoning Province “Research on Epigenetics of Hereditary Non-polyposis Colorectal Cancer MLH1”(No. 201102281)and “Family Research on Hereditary Non-polyposis Colorectal Cancer in Northeast China” (No. 20062053).