Abstract
Context: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes.
Objective: We aimed to determine miRNA expression levels in plasma of children with DCM.
Materials and methods: Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children.
Results: The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCM patients.
Discussion: miRNA level differences may provide the chance of using these miRNAs as new biomarkers.