Testosterone supplementation's effects on age-related bladder remodeling – experimental study in rats

Figures & data

Table 1. Average body weights in grams of the mice over time and groups involved in the experiment.

	Average weights (g)
Groups	D0	D28	D56
Testosterone	438*	427.9*	418.9*
Control	449.5*	420*	405*

*(p > 0.05), (Kruskal–Wallis test).

Figure 1. Box-plot of the values of serum testosterone in the testosterone and control groups on D0 (beginning of the experiment) and D56 (animal sacrifice).

Figure 2. Volumetric density of the collagen fibers of the bladder wall in different groups. p < 0.000; t test.

Table 2. Descriptive analysis on collagen fibers of bladder wall in both groups.

	Volumetric density (Vv) -- %
	Testosterone	Control
Mean	37.02	55.95
SD	8.3	9.45
Minimum	19.05	35.71
25th Percentile	33.33	47.62
Median	35.71	55.95
Maximum	54.76	71.43
75th Percentile	42.26	62.49
Standard Error	1.86	2.11
95% CI	33.33–40.48	51.80–60.09

Figure 3. Picrosirius stained bladder wall of the control group analyzed under polarized light microscopy (400×).

Figure 4. Picrosirius stained bladder wall of the testosterone group analyzed under polarized light microscopy (400×).