Late-onset hypogonadism among old and middle-aged males with prediabetes in Polish population

Figures & data

Table 1. Characteristic of patients with prediabetes and control group.

Parameter	Prediabetes No. 196	Control No. 184	p*
Age (years)	68.4 ± 3.1	65.8 ± 3.4	NS
TT (nmol/l)	11.78 ± 1.76	16.37 ± 1.6	0.001
cFT (nmol/l)	0.328 ± 0.08	0.385 ± 0.07	0.005
DHEA (ng/mL)	2467 ± 133	2534 ± 138	NS
LH (IU/l)	6.7 ± 1.3	3.3 ± 1.44	0.05
FSH (IU/l)	8.7 ± 0.9	6.1 ± 0.7	0.05
Prolactin (ng/ml)	11 ± 3.8	12 ± 3.7	NS
Estradiol (pg/ml)	32.6 ± 3.6	26.9 ± 3.5	0.05
SHBG (nmol/l)	31.6 ± 2.2	26.8 ± 2.4	0.05
BMI (kg/m^2)	29.6 ± 1.5	27.1 ± 0.9	0.01
Waist circumference (cm)	104 ± 7.5	98 ± 6	0.02
HbA1c (%)	6,2 ± 1.3	5.3 ± 1.34	0.02
FPG (mg/dl)*	117 ± 4.6	94 ± 4.8	0.001
Glucose in OGTT (mg/dl)*	131 ± 6.1	118 ± 6.2	0.05
Systolic pressure (mmHg)	146 ± 17.2	139 ± 17.3	NS
Diastolic pressure (mmHg)	94 ± 12.4	90 ± 8.7	NS
Cholesterol (mg/dl)	221 ± 16	205 ± 15	0.05
Triglicerides (mg/dl)	169 ± 12	155 ± 14	0.02
HDL-cholesterol (mg/dl)	36.2 ± 4.6	46.3 ± 4.2	0.002
LDL-cholesterol (mg/dl)	147 ± 12	135 ± 11	0.05

BMI – body mass index, TT – total testosterone, cFT – calculated free testosterone, LH – luteinizing hormone, DHEA – dehydroepiandrosterone, FSH – follicle stimulating hormone, SHBG – sex hormone binding globuline, FPG – fasting plasma glucose.

*p shows differences between both groups.

Figure 1. Total and calculated free testosterone concentrations in men with LOH in prediabetes and control group.

Table 2. Total testosterone (TT) and calculated free testosterone (cFT) concentrations in prediabetic men with LOH after dividing according glycemic control disorders.

	Prediabetes and LOH
Parameter	All (n = 60)	IFG (n = 32)	IGT (n = 28)	p*
TT (nmol/l)	9.45 ± 0.9	9.86 ± 0.9	9.22 ± 0.85	0.05
cFT (nmol/l)	0.235 ± 0.08	0.248 ± 0.06	0.226 ± 0.07	0.02

*p shows differences between patients with IFG and IGT in LOH group among prediabetic men.

Table 3. The prevalence (no. pts., %) of comorbidities in prediabetic men and in control group.

	Prediabetic
Parameter	All n = 196	LOH n = 60	Eugonadal n = 136	p*	Control n = 184	p**
Obesity	160 (82)	53 (88)	100 (73)	0.02	80 (44)	0.02
Current smoker	65 (32)	20 (33)	45 (33)	NS	61 (33)	NS
Hypertension	123 (62)	40 (66)	93 (68)	NS	92 (50)	NS
MetS	162 (66)	48 (80)	92 (67)	0.05	96 (52)	0.02
CVD	52 (26)	15 (25)	34 (25)	NS	36 (20)	0.05

MetS – metabolic syndrome, CVD – cardiovascular disease.

*p shows differences between LOH and eugonadal subgroups among prediabetic patients.

**p shows differences between prediabetic and control group.