Protective effect of Morus alba leaves on haloperidol-induced orofacial dyskinesia and oxidative stress

Figures & data

Figure 1.  Effect of coadministration of Morus alba leaf extract (MAE) on chronic haloperidol-induced (a) vacuous chewing movements (VCMs) and (b) tongue protrusions. Each column represents mean ± SEM (n = 5). ^aCompared with vehicle-treated group; ^bcompared with haloperidol-treated group; *p < 0.05; **p < 0.01 (one-way ANOVA followed by Dunnett’s test).

Table 1.  Effects of coadministration of Morus alba leaf extract (MAE) on haloperidol-induced alterations in rat brain CAT, SOD, LPO, NO, and protein.

Treatment (mg/kg)	CAT (μmol of H2O2 decomposed/min/mg protein)	SOD (U/mg protein)	LPO (nmol of MDA/ mg protein)	NO (μmol/ mL homogenate)	Protein (μg protein/mg of tissue)
Vehicle	4.3 ± 0.4	12.5 ± 4.4	18.3 ± 2.3	0.16 ± 0.03	98.6 ± 31.2
Haloperidol	1.5 ± 1.0	4.5 ± 2.2	33.8 ± 2.7^a*	1.2 ± 0.4^a*	34.6 ± 4.5
HAL + MAE 100	4.0 ± 0.7	6.2 ± 2.4	29.5 ± 2.1	0.44 ± 0.2	45.2 ± 2.3
HAL + MAE 200	5.9 ± 0.9^b**	7.6 ± 2.5	13.7 ± 3.4^b**	0.18 ± 0.02^b*	68.9 ± 17.9
HAL + MAE 300	4.7 ± 0.4^b*	7.0 ± 0.7	19.1 ± 2.4^b*	0.20 ± 0.2^b*	77.2 ± 8.4
MAE 300	5.4 ± 0.5^b**	17.4 ± 1.6^b**	11.3 ± 0.8^b**	0.19 ± 0.04^b*	105.5 ± 28.0

Values are expressed as mean ± SEM (n = 5).

^aCompared with vehicle-treated group; ^bcompared with haloperidol-treated group.

*p < 0.05; **p < 0.01 (one-way ANOVA followed by Dunnett’s test).