Toxicity study of Vernonia cinerea

Figures & data

Figure 1.  Histological examination: liver (A), kidney (B), lungs (C), and spleen (D).

Table 1.  Effect of Vernonia cinerea crude extract^a on organ-to-body weight index (%) in mice.

Organ	Male		Female
	Control	Crude extract	Control	Crude extract
Kidney	1.42 ± 0.01	1.40 ± 0.01	1.36 ± 0.01	1.35 ± 0.01
Liver	7.11 ± 0.06	7.12 ± 0.06	6.95 ± 0.01	6.62 ± 0.01
Lung	1.22 ± 0.01	1.29 ± 0.01	1.12 ± 0.01	1.10 ± 0.01
Spleen	0.51 ± 0.02	0.52 ± 0.02	0.46 ± 0.01	0.48 ± 0.01
Body weight (g)	31 ± 0.57	32 ± 0.56	30 ± 0.51	29 ± 0.49

Organ body index was calculated as (organ weight × 100)/body weight.

^aCrude extract of V. cinerea was administered to mice at a dose of 2000 mg/kg. Values are mean ± SD (n = 7).

Figure 2.  Toxic effects of Vernonia cinerea methanol extract after 6 h using brine shrimp lethality assay.

Figure 3.  Toxic effects of Vernonia cinerea methanol extract after 24 h using brine shrimp lethality assay.