Semen Hoveniae extract protects against acute alcohol-induced liver injury in mice

Figures & data

Table 1.  Effects of Semen Hoveniae extract (SHE) on blood alcohol content in mice.

Group	Mice (n)	Blood alcohol content (mg/dL)
Alcohol	10	394.26 ± 69.27
SHE (150 mg/kg) + alcohol	10	343.72 ± 61.34
SHE (300 mg/kg) + alcohol	10	315.83 ± 57.45*
SHE (600 mg/kg) + alcohol	10	283.31 ± 63.42**

Note. *p < 0.05 **p < 0.01 compared with alcohol group. Data are expressed as mean ± SEM.

Table 2.  Effects of SHE on levels of serum ALT and AST and hepatic TG.

Group	Serum ALT level (U/L)	Serum AST level (U/L)	Hepatic TG level (mmol/L)
Control	51.80 ± 3.43	147.52 ± 7.41	2.56 ± 0.06
Alcohol	74.40 ± 2.87^††	302.56 ± 20.00^††	2.97 ± 0.05^††
SHE (150 mg/kg) + alcohol	61.80 ± 3.49*	263.88 ± 17.12	2.88 ± 0.15
SHE (300 mg/kg) + alcohol	52.70 ± 4.00**	198.63 ± 19.66**	2.66 ± 0.10*
SHE (600 mg/kg) + alcohol	49.20 ± 3.14**	188.74 ± 10.96**	2.54 ± 0.05**

Note. ^†p < 0.05, ^††p < 0.01 compared with control group; *p < 0.05, **p < 0.01 compared with alcohol group. Data are expressed as mean ± SEM. Ten animals were used per group.

Table 3.  Effects of SHE on some hepatic parameters.

Group	Hepatic MDA level (nmol/g)	Hepatic ADH level (µmol/min.L)	Hepatic GSH level (nmol/g)	Hepatic GST level (nmol/min.mg)	Hepatic SOD level (U/mg)
Control	35.10 ± 1.93	272.45 ± 12.01	6.50 ± 012	93.84 ± 3.38	151.80 ± 6.6
Alcohol	47.20 ± 2.31^††	384.16 ± 14.37^††	5.54 ± 0.21^††	71.86 ± 4.02^††	94.40 ± 6.98^††
SHE (150 mg/kg) + alcohol	44.50 ± 1.08	335.81 ± 17.53	6.85 ± 0.15**	84.67 ± 3.46*	131.80 ± 9.50*
SHE (300 mg/kg) + alcohol	36.40 ± 1.88**	312.03 ± 13.15**	7.90 ± 0.18**	95.13 ± 4.70**	142.70 ± 10.33**
SHE (600 mg/kg) + alcohol	32.70 ± 1.87**	307.31 ± 10.36**	8.74 ± 0.22**	123.43 ± 7.31**	149.20 ± 6.31**

Note. ^†p < 0.05, ^††p < 0.01 compared with control group; *p < 0.05, **p < 0.01 compared with alcohol group. Data are expressed as mean ± SEM. Ten animals were used per group.