Effect of Pelargonium reniforme roots on alcohol-induced liver damage and oxidative stress

Figures & data

Table 1.  Polyphenolic contents of the aqueous root extract of P. reniforme.

Phenolic compounds	P. reniforme root extract
Total phenol^a	300.90 ± 0.10
Total flavonoid^b	16.60 ± 0.10
Total flavonol^c	12.13 ± 0.01
Total proanthocyanidin^d	271.30 ± 0.20

Note. n = 3, mean ± SD.

^aExpressed as mg tannic acid/g of dry plant material.

^bExpressed as mg quercetin/g of dry plant material.

^cExpressed as mg quercetin/g of dry plant material.

^dExpressed as mg catechin/g of dry plant material.

Figure 1.  DPPH radical scavenging activity of the aqueous extract of P. reniforme roots.

Figure 2.  ABTS radical scavenging activity of the aqueous extract of P. reniforme roots.

Figure 3.  Total ferric reductive potential of the aqueous extract of P. reniforme roots.

Table 2.  Effect of aqueous extract of P. reniforme roots on hepatic markers in the serum of control and ethanol-administered rats.

Group	AST (U/L)	ALT (U/L)	ALP (U/L)	GGT (U/L)	Total bilirubin (µmol/L)	Unconjugated bilirubin (µmol/L)	Conjugated bilirubin (µmol/L)
Group 1	356.00 ± 0.00^a	66.50 ± 19.21^a	394.50 ± 5.00^a	9.25 ± 1.50^a	11.50 ± 5.20^a	10.50 ± 5.20^a	1.00 ± 0.00^c
Group 2	117.00 ± 20.00^e	42.75 ± 6.90^c	309.00 ± 0.00^b	7.00 ± 1.83^ba	5.75 ± 1.50^b	3.25 ± 1.30^c	2.50 ± 0.58^a
Group 3	140.75 ± 12.30^cbd	60.75 ± 5.25^ba	211.00 ± 76.81^cd	7.75 ± 0.96^ba	8.00 ± 2.16^b	6.75 ± 2.40^b	1.25 ± 0.50^bc
Group 4	141.75 ± 10.20^cbd	55.25 ± 4.50^bac	260.00 ± 41.70^cb	7.25 ± 1.71^ba	7.75 ± 2.75^b	6.00 ± 0.60^b	1.75 ± 1.50^bac
Group 5	145.00 ± 8.98^cb	54.75 ± 4.35^bac	244.75 ± 63.80^cbd	6.00 ± 1.15^b	7.00 ± 1.41^b	5.50 ± 0.60^b	1.50 ± 0.58^bac
Group 6	123.75 ± 7.50^ed	62.75 ± 15.11^a	285.50 ± 43.00^cb	7.67 ± 0.58^ba	7.25 ± 3.30^b	5.25 ± 1.90^b	2.00 ± 1.41^bac
Group 7	134.50 ± 12.01^ced	58.75 ± 5.25^ba	285.75 ± 82.10^cb	8.50 ± 1.00^a	6.75 ± 0.50^b	5.50 ± 2.70^b	1.25 ± 0.50^bc
Group 8	126.00 ± 19.34^ced	54.50 ± 10.25^bac	240.00 ± 77.13^cbd	7.25 ± 0.96^ba	7.00 ± 1.41^b	5.33 ± 1.29^b	1.67 ± 1.15^bac
Group 9	159.25 ± 25.73^b	47.25 ± 8.30^bc	174.00 ± 86.12^d	7.50 ± 3.00^ba	7.50 ± 0.58^b	5.25 ± 0.00^b	2.25 ± 1.26^ba
Group 10	141.75 ± 10.90^cbd	56.25 ± 6.60^bac	272.00 ± 9.24^cb	5.50 ± 1.00^b	7.25 ± 0.50^b	6.00 ± 0.96^b	1.25 ± 0.50^bc

Note. Values are expressed as mean ± SD for six rats in each group. Values not sharing a common superscript differ significantly at p < 0.05. AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; GGT, gamma glutamyl transferase.

Table 3.  Effect of aqueous extract of P. reniforme roots on the serum protein components of control and ethanol-administered rats.

Group	Total proteins (g/L)	Albumin (g/L)	Globulin (g/L)
Group 1	71.00 ± 0.00^b	18.00 ± 0.00^a	53.00 ± 0.00^ba
Group 2	73.25 ± 1.50^ba	19.50 ± 1.00^a	53.75 ± 2.06^ba
Group 3	76.25 ± 6.60^ba	19.00 ± 2.16^a	57.25 ± 5.97^ba
Group 4	79.00 ± 3.56^a	20.00 ± 1.15^a	59.00 ± 3.16^a
Group 5	77.25 ± 2.36^ba	19.00 ± 4.83^a	58.25 ± 2.63^a
Group 6	76.50 ± 5.92^ba	20.50 ± 1.00^a	56.00 ± 5.35^ba
Group 7	74.50 ± 5.26^ba	20.00 ± 0.82^a	54.50 ± 4.51^ba
Group 8	74.00 ± 4.24^ba	18.75 ± 2.36^a	55.25 ± 2.50^ba
Group 9	75.00 ± 2.45^ba	20.00 ± 3.16^a	56.75 ± 1.50^ba
Group 10	75.75 ± 3.59^ba	19.00 ± 1.15^a	55.75 ± 3.59^ba

Note. Values are expressed as mean ± SD for six rats in each group. Values not sharing a common superscript differ significantly at p < 0.05.