Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)

Figures & data

Figure 1.  Gastroprotective activity of Solidago chilensis aqueous extract. (A) Representative stomach of control group. (B) Representative stomach of group treated with 1200 mg/kg of extract. Arrows indicate some of the ulcers produced by ethanol. Bars = 5 mm.

Table 1.  Effect of Solidago chilensis aqueous extract (AE) against gastric lesions induced by ethanol in mice.

Treatment (dose: mg/kg)	Ulcer index	Prevention from Ulcer^a	Inhibition (%)
Control	34.2 ± 3.2	–	–
AE (125)	13.5 ± 1.7*	0/6	61.4
AE (250)	8.9 ± 1.7*	0/6	75.1
AE (400)	7.4 ± 1.7*	0/6	78.4
AE (800)	6.4 ± 2.1*	2/6	81.3
AE (1200)	4.5 ± 1.9*	2/6	86.8
AE (2000)	2.9 ± 1.6*	2/6	91.5
Omeprazole (10)	8.1 ± 1.4*	0/6	76.5
Values are expressed as mean ± SEM (n = 6). Statistical comparison was performed using Analysis of variance (ANOVA) followed by Tukey’s test. * Statistically significant vs. control group (P < 0.05). ^ª Number of stomachs completely prevented from any bleeding or lesion.