Evaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella

Figures & data

Figure 1.  Inhibition of phospholipase A2 activity induced by compounds 1–5. Each of these compounds was previously incubated with each of sPLA2.

Figure 2.  Inhibitory effects of the CH₂Cl₂ (CH₂Cl₂-Bu), and the EtOAc phases from B. uncinella (EtOAc-Bu) on edema induction by isolated secretory PLA2 from Crotalus durissus terricus or carrageenan. In panel A, the effects of prior incubation of PLA2 with CH₂Cl₂-Bu (PLA2-CH₂Cl₂; –▴–), or EtOAc-Bu (PLA2-EtOAc; –▾–) on edema induction by PLA2 are displayed (results with native PLA2 are shown by – ▪ –). In panel B, the inhibitory effects of prior intravenous injection of experimental animals with CH₂Cl₂-Bu (– • –), or EtOAc-Bu (–▾–) on edema induction by PLA2 are displayed (results with control animals are shown by – ▪ –). In panel C, the inhibitory effects of prior intravenous injection of experimental animals with CH₂Cl₂-Bu (–▴ –), or EtOAc-Bu (–▾–) on edema induction by 2% carrageenan are displayed (results with control animals are shown by – ▪ –). Each point represents the mean value ± SEM (n = 5); asterisks indicate significant differences in comparison with control (P < 0.05).

Figure 3.  (A) Effect of compounds 1–5 against edema induced by native sPLA2 from the Crotalus durissus terrificus. (B) Effect of previous incubation of compounds 1–5 against the edema induced by carrageenan. *P < 0.05 compared with the corresponding control group.