The effect of Hypericum perforatum on isolated rat aorta

Figures & data

Table 1.  Contractions (mg) to phenylephrine and KCl and relaxation (%) to acetylcholine and sodium nitroprusside in aortic rings with endothelium from control and HP treated animals.

		Phe	KCl	Ach	SNP
Control	Emax	1131.73 ± 164.11	745.58 ± 66.73	94.61 ± 2.65	108.82 ± 5.06
	pD2	7.19 ± 0.14		7.61 ± 0.26	8.35 ± 0.10
Hypericum	Emax	477.40 ± 39.94*	112.58 ± 26.58^†	87.79 ± 9.40	106.43 ± 7.45
	pD2	6.77 ± 0.07*		7.42 ± 0.21	8.32 ± 0.10

Values are mean ± SEM (n = 6).

*p < 0.05, ^†p < 0.001 control vs. Hypericum.

Phe, phenylephrine; Ach, acetylcholine; SNP, sodium nitroprusside.

Figure 1.  Effect of HP (0.05 mg/ml) on phenylephrine contraction in aortic rings with endothelium. *p < 0.05 control vs. Hypericum.

Figure 2.  Effect of HP (0.05 mg/ml) on acetylcholine relaxation in aortic rings with endothelium.

Figure 3.  Effect of HP (0.05 mg/ml) on sodium nitroprusside relaxation in aortic rings with endothelium.