Evaluation of sub-chronic oral toxicity of Joloo: A traditional medicinal decoction

Figures & data

Table 1.  Effect of Joloo on some blood parameters and body weight of albino rats in 28 days.

Dose mg kg^−1	Weight kg^−1	PCV (%)	RBC (1012/L)	WBC (109/L)	Neutrophils (%)
Control	142.1 ± 7.4	44.0 ± 2.8	1.62 ± 2.1	37.8 ± 0.9	23.8 ± 6.9
400	151.6 ± 4.2	39.5 ± 0.7	1.14 ± 0.6*	47.7 ± 1.1	15.3 ± 4.6
800	140.7 ± 4.1	39.8 ± 2.6	0.98 ± 0.5*	53.8 ± 0.4	21.0 ± 5.9
1600	168.3 ± 4.5*	38.7 ± 0.8	0.85 ± 1.1*	60.6 ± 1.7	17.7 ± 2.5

Data represents the mean ± SEM blood parameters and weight of rats (N = 10).

*P < 0.05 significantly different from control (Student’s t-test).

Table 2.  Effect of Joloo on rat liver enzymes activities and serum biochemical analytes post 28 days treatment.

Dose mg kg^−1	ALP IU L^−1	ALT IU L^−1	AST IU L^−1	Cholesterol mg dL^−1	C/Knac U L^−1	Creatinine mg dL^−1
Control	27.5 ± 37.3	27.1 ± 0.4	84.1 ± 5.5	59.9 ± 5.5	23.2 ± 8.6	1.64 ± 0.1
400	17.2 ± 44.0	25.3 ± 0.6	78.9 ± 3.3	56.5 ± 4.9	19.9 ± 1.6	1.51 ± 0.2
800	17.5 ± 44.0	26.7 ± 0.7	88.3 ± 4.5	58.7 ± 3.5	18.4 ± 4.9	1.55 ± 0.1
1600	47.8 ± 6.7	29.4 ± 3.2	88.8 ± 10.3	62.6 ± 0.8	17.3 ± 3.7	1.84 ± 0.0

Data represents the mean ± SEM of biochemical analytes from liver of rats (N = 10).

*P < 0.05 significantly different from control (Student’s t-test).

Figure 1.  Superoxide dismutase and catalase activities (mg dL⁻¹).

Figure 2.  Mean relative organ weight after 28 days.

Figure 3.  Gross and histologic pathology.