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Research Article

Schistosomicidal and molluscicidal activities of aminoalkylamino substituted neo- and norneocryptolepine derivatives

Samia El BardicyDepartment of Medical Malacology and Schistosome Biological Supply Centre, Theodor Bilharz Research Institute, Imbaba, EgyptCorrespondence[email protected]

Ibrahim El SayedDepartment of Chemistry, Faculty of Science, Menoufiya University, Shebin El Kom, Egypt

Fouad YousifDepartment of Medical Malacology and Schistosome Biological Supply Centre, Theodor Bilharz Research Institute, Imbaba, Egypt

Pieter Van der VekenLaboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium

Achiel HaemersLaboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium

Koen AugustynsLaboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium

Luc PietersLaboratory of Pharmacognosy and Pharmaceutical Analysis, University of Antwerp, Antwerp, Belgium

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Figures & data

Figure 1. Structures of chloroquine (1), cryptolepine (2), neocryptolepine (3).

Table 1. In vitro schistosomicidal activity of neocryptolepine (5-methyl-5H-indolo[2,3- b]quinoline) derivatives on adult Schistosoma mansoni worms (results after 5 days exposure).

Display Table

Table 2. In vitro schistosomicidal activity of norneocryptolepine (quinindoline, 6H-indolo [2,3-b]quinoline) derivatives for Schistosoma mansoni worms (results after 5 days exposure).

Display Table

Figure 2. General structures of neo- (4) and norneocryptolepine analogs (5).

Table 3. Molluscicidal activity of substituted neo- and norneocryptolepines on Biomphalaria alexandrina snails (results after 24 h).

Display Table

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Schistosomicidal and molluscicidal activities of aminoalkylamino substituted neo- and norneocryptolepine derivatives

Table 1. In vitro schistosomicidal activity of neocryptolepine (5-methyl-5H-indolo[2,3- b]quinoline) derivatives on adult Schistosoma mansoni worms (results after 5 days exposure).

Table 2. In vitro schistosomicidal activity of norneocryptolepine (quinindoline, 6H-indolo [2,3-b]quinoline) derivatives for Schistosoma mansoni worms (results after 5 days exposure).

Table 3. Molluscicidal activity of substituted neo- and norneocryptolepines on Biomphalaria alexandrina snails (results after 24 h).

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Schistosomicidal and molluscicidal activities of aminoalkylamino substituted neo- and norneocryptolepine derivatives

Figures & data

Table 1. In vitro schistosomicidal activity of neocryptolepine (5-methyl-5H-indolo[2,3- b]quinoline) derivatives on adult Schistosoma mansoni worms (results after 5 days exposure).

Table 2. In vitro schistosomicidal activity of norneocryptolepine (quinindoline, 6H-indolo [2,3-b]quinoline) derivatives for Schistosoma mansoni worms (results after 5 days exposure).

Table 3. Molluscicidal activity of substituted neo- and norneocryptolepines on Biomphalaria alexandrina snails (results after 24 h).

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