In vivo antiplasmodial activities of aqueous extract of Bridelia ferruginea stem bark against Plasmodium berghei berghei in mice

Figures & data

Table 1.  Curative effect of aqueous stem bark extract of BF against P. berghei in mice.

Drug (mg/kg)	Mean parasitemia count		% Parasitemia inhibition	Mean survival time (Days)
	Pre (Day 3)	Post (Day 7)
Normal saline: 10 (ml/kg)	27.65 ± 0.10	35.57 ± 0.49*	0	9.00 ± 2.0
B. ferruginea: 100	22.11 ± 0.14	12.03 ± 0.25*	66.18	25.50 ± 1.2
200	24.08 ± 0.12	10.68 ± 0.12*	69.97	28.00 ± 0.9
400	25.05 ± 0.17	7.67 ± 0.22*	78.44	29.20 ± 0.5
Chloroquine: 10	23.08 ± 0.90	2.30 ± 0.33*	93.53	30.00 ± 0.0

Results are mean count ± S.E.M (n = 6),

*significantly different from control at p < 0.05.

Table 2.  Result of phytochemical screening of BF aqueous stem back extract.

Metabolite tested	Alk	Tan	Sap	Flav	Terp	Sterols	Glyc	Anthra	Res
Result	+	+	+	+	+	+	−	−	+

Alk: alkaloids; Tan: tannins; Sap: saponins; Flav: flavonoids; Terp: terpenes; Glyc: glycosides; Anthra: anthranquinones; Res: Resins; +: Positive; −: negative.

Table 3.  Suppressive effect of aqueous stem bark extract of BF against P. berghei in mice.

Drug (mg/kg)	Parasitemia count	% inhibition
Normal Saline: 10 (ml/kg)	33.87 ± 0.70	0
B. ferruginea: 100	7.86 ± 0.17	77*
200	4.24 ± 0.27	87*
400	1.78 ± 0.16	95*
Chloroquine: 10	1.52 ± 0.24	96*

Results are mean count ± S.E.M (n = 6),

*significantly different from control at p < 0.05.