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Research Article

Antinociceptive and anti-inflammatory effects of olive oil (Olea europeae L.) in mice

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Pages 332-337 | Received 19 Jan 2011, Accepted 22 Jun 2011, Published online: 15 Nov 2011

Figures & data

Figure 1.  Effect of intraperitoneally administration of morphine (Mor.) and olive oil at doses of 1, 5 and 10 ml/kg body wt. on first-phase of formalin-induced pain. Each column represents mean ± SEM for eight mice. ***p < 0.001 different from control group. Intact animals served as controls.

Figure 1.  Effect of intraperitoneally administration of morphine (Mor.) and olive oil at doses of 1, 5 and 10 ml/kg body wt. on first-phase of formalin-induced pain. Each column represents mean ± SEM for eight mice. ***p < 0.001 different from control group. Intact animals served as controls.

Figure 2.  Effect of intraperitoneally administration of morphine (Mor.) and olive oil at doses of 1, 5 and 10 ml/kg body wt. on second-phase of formalin-induced pain. Each column represents mean ± SEM for eight mice. ***p < 0.001 different from control group. Intact animals served as controls.

Figure 2.  Effect of intraperitoneally administration of morphine (Mor.) and olive oil at doses of 1, 5 and 10 ml/kg body wt. on second-phase of formalin-induced pain. Each column represents mean ± SEM for eight mice. ***p < 0.001 different from control group. Intact animals served as controls.

Figure 3.  Effect of the intraperitoneally administration of morphine (Mor.) and olive oil at doses of 1, 5 and 10 on hot plate test. Thermal antinociceptive latency before, and at 15, 30, 45, and 60 min after the treatment was measured. Each column represents mean ± SEM for eight mice. **p < 0.01, ***p < 0.001 different from control group. Intact animals served as controls.

Figure 3.  Effect of the intraperitoneally administration of morphine (Mor.) and olive oil at doses of 1, 5 and 10 on hot plate test. Thermal antinociceptive latency before, and at 15, 30, 45, and 60 min after the treatment was measured. Each column represents mean ± SEM for eight mice. **p < 0.01, ***p < 0.001 different from control group. Intact animals served as controls.

Figure 4.  Effect of intraperitoneally administration of indomethacin (Indo.) and olive oil at doses of 1, 5 and 10 ml/kg body wt. on acetic acid-induced writhing response in mice. Each column represents mean ± SEM for eight mice. ***p < 0.001 different from control group. Intact animals served as controls.

Figure 4.  Effect of intraperitoneally administration of indomethacin (Indo.) and olive oil at doses of 1, 5 and 10 ml/kg body wt. on acetic acid-induced writhing response in mice. Each column represents mean ± SEM for eight mice. ***p < 0.001 different from control group. Intact animals served as controls.

Figure 5.  Effect of intraperitoneally administration of dexamethasone (Dex.) and olive oil at doses of 1, 5 and 10 ml/kg body wt. on weight ear edema induced by xylene in mice. Each column represents mean ± SEM for eight mice. *p < 0.05, ***p < 0.001 different from control group. Intact animals served as controls.

Figure 5.  Effect of intraperitoneally administration of dexamethasone (Dex.) and olive oil at doses of 1, 5 and 10 ml/kg body wt. on weight ear edema induced by xylene in mice. Each column represents mean ± SEM for eight mice. *p < 0.05, ***p < 0.001 different from control group. Intact animals served as controls.

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