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Research Article

Superoxide dismutase and catalase activities in rat hippocampus pretreated with garcinielliptone FC from Platonia insignis

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Pages 453-457 | Received 26 Jun 2011, Accepted 03 Aug 2011, Published online: 01 Dec 2011

Figures & data

Figure 1.  Structure chemistry of GFC isolated from the seeds of P. insignis.

Figure 1.  Structure chemistry of GFC isolated from the seeds of P. insignis.

Figure 2.  Effects of DMF, EAF, EE, HE, and GFC on SOD activities in rat hippocampus. Male rats (250–280 g; 2 months old) were treated with a single dose of DMF (2 mg/kg, intraperitoneal, i.p., n = 9), EAF (2 mg/kg, intraperitoneal, i.p., n = 9), EE (2 mg/kg, intraperitoneal, i.p., n = 9), HE (2 mg/kg, intraperitoneal, i.p., n = 9), GFC (2 mg/kg, intraperitoneal, i.p., n = 9), and the vehicle (Tween 80 0.05% dissolved in 0.9% saline) (i.p., n = 12, Control). Results are expressed as means ± S.E.M. for the number of animals shown above in parenthesis. Results were expressed as U/mg of protein. The Student–Newman–Keuls t-test was used for multiple comparisons of means of two groups of data. Differences in experimental groups were determined by two-tailed analysis of variance; ap < 0.05, when compared to vehicle group (ANOVA and Student–Newman–Keuls as post hoc t-test); bp < 0.05, when compared to DMF group (ANOVA and Student–Newman as post hoc t-test); cp < 0.05, when compared to EAF group (ANOVA and Student–Newman–Keuls as post hoc t-test); dp < 0.05, when compared to EE group (ANOVA and Student–Newman–Keuls as post hoc t-test).

Figure 2.  Effects of DMF, EAF, EE, HE, and GFC on SOD activities in rat hippocampus. Male rats (250–280 g; 2 months old) were treated with a single dose of DMF (2 mg/kg, intraperitoneal, i.p., n = 9), EAF (2 mg/kg, intraperitoneal, i.p., n = 9), EE (2 mg/kg, intraperitoneal, i.p., n = 9), HE (2 mg/kg, intraperitoneal, i.p., n = 9), GFC (2 mg/kg, intraperitoneal, i.p., n = 9), and the vehicle (Tween 80 0.05% dissolved in 0.9% saline) (i.p., n = 12, Control). Results are expressed as means ± S.E.M. for the number of animals shown above in parenthesis. Results were expressed as U/mg of protein. The Student–Newman–Keuls t-test was used for multiple comparisons of means of two groups of data. Differences in experimental groups were determined by two-tailed analysis of variance; ap < 0.05, when compared to vehicle group (ANOVA and Student–Newman–Keuls as post hoc t-test); bp < 0.05, when compared to DMF group (ANOVA and Student–Newman as post hoc t-test); cp < 0.05, when compared to EAF group (ANOVA and Student–Newman–Keuls as post hoc t-test); dp < 0.05, when compared to EE group (ANOVA and Student–Newman–Keuls as post hoc t-test).

Figure 3  Effects. of DMF, EAF, EE, HE, and GFC on CAT activities in rat hippocampus. Male rats (250–280g; 2 months old) were treated with a single dose of DMF (2 mg/kg, intraperitoneal, i.p., n = 9), EAF (2 mg/kg, intraperitoneal, i.p., n = 9), EE (2 mg/kg, intraperitoneal, i.p., n = 9), HE (2 mg/kg, intraperitoneal, i.p., n = 9), GFC (2 mg/kg, intraperitoneal, i.p., n = 9), and the vehicle (Tween 80 0.05% dissolved in 0.9% saline) (i.p., n = 12, Control). Results are expressed as means ± S.E.M. for the number of animals shown inside in parenthesis. Results were expressed as mmol/min/mg of protein. The Student–Newman–Keuls t-test was used for multiple comparisons of means of two groups of data. Differences in experimental groups were determined by two-tailed analysis of variance.

Figure 3  Effects. of DMF, EAF, EE, HE, and GFC on CAT activities in rat hippocampus. Male rats (250–280g; 2 months old) were treated with a single dose of DMF (2 mg/kg, intraperitoneal, i.p., n = 9), EAF (2 mg/kg, intraperitoneal, i.p., n = 9), EE (2 mg/kg, intraperitoneal, i.p., n = 9), HE (2 mg/kg, intraperitoneal, i.p., n = 9), GFC (2 mg/kg, intraperitoneal, i.p., n = 9), and the vehicle (Tween 80 0.05% dissolved in 0.9% saline) (i.p., n = 12, Control). Results are expressed as means ± S.E.M. for the number of animals shown inside in parenthesis. Results were expressed as mmol/min/mg of protein. The Student–Newman–Keuls t-test was used for multiple comparisons of means of two groups of data. Differences in experimental groups were determined by two-tailed analysis of variance.

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