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Research Article

Simultaneous determination of synephrine, arecoline, and norisoboldine in Chinese patent medicine Si-Mo-Tang oral liquid preparation by strong cation exchange high performance liquid chromatography

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Pages 832-838 | Received 25 Apr 2011, Accepted 31 Oct 2011, Published online: 03 Apr 2012

Figures & data

Table 1.  Chromatographic parameters of resolution, theoretical plate number, symmetry factor, and peak purity of arecoline, synephrine, and norisoboldine in SMT on SCX and ZORBAX SB-C18 columns.

Figure 1.  Structures of arecoline, synephrine, and norisoboldine.

Figure 1.  Structures of arecoline, synephrine, and norisoboldine.

Figure 2.  HPLC chromatograms of reference standards (A) and SMT sample (B) separated on an Agilent ZORBAX SB-C18 column (250 × 4.6 mm, 5 µm) (1: synephrine; 2: arecoline; 3: norisoboldine).

Figure 2.  HPLC chromatograms of reference standards (A) and SMT sample (B) separated on an Agilent ZORBAX SB-C18 column (250 × 4.6 mm, 5 µm) (1: synephrine; 2: arecoline; 3: norisoboldine).

Figure 3.  HPLC chromatograms of reference standards (A) and SMT sample (B) separated on an Agilent SCX column (250 × 4.6 mm, 5 µm) (1: synephrine; 2: norisoboldine; 3: arecoline).

Figure 3.  HPLC chromatograms of reference standards (A) and SMT sample (B) separated on an Agilent SCX column (250 × 4.6 mm, 5 µm) (1: synephrine; 2: norisoboldine; 3: arecoline).

Table 2.  Accuracy and recovery of synephrine, arecoline and norisoboldine at different concentrations (n = 3).

Table 3.  Determination of synephrine, arecoline and norisoboldine from 26 batches of SMT (n = 3).

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