Edematogenic activity of a sulfated galactan from the red marine algae Gelidium crinale

Figures & data

Figure 1.  Structures of the sulfated galactan of Gelidium crinale and λ carrageenan. (A)α- and β-galactopyranose with variable sulfatation pattern (β-D-galactopyranose-2-sulfate-O-α-D-galactopyranose-2,3 sulfate) (Source: Adapted from Pereira et al., 2005). (B) β-D-galactopyranose-2-sulfate-O-α-D-galactopyranose-2,6-sulfate (λ carrageenan) (Perez et al., 1992).

Figure 2.  Edematogenic effect of SG-Gc. Paw edema was induced by SG-Gc (1 mg/kg, s.c) (A–D)or (A, B) λ carrageenan (300 μg/paw) and measured at zero time and from 0.5–8 h by a plethysmometer. (C) Pyrilamine (10 mg/kg) or compound 48/80 (0.6 mg/kg on Days 1–3 and 1.2 mg/kg on Day 4) were injected i.p. 30 min before the injection of SG-Gc (1 mg/kg). (D) Indomethacin (5 mg/kg; ), L-NAME (25 mg/kg; i.v.) or pentoxifylline (90 mg/kg; ) were injected 1 h before SG-Gc injection (1 mg/kg). Mean ± SEM (n = 6). ANOVA and Bonferroni’s test. *p < 0.05 compared to saline and #p < 0.05 to SG-Gc.

Pereira MG, Benevides NM, Melo MR, Valente AP, Melo FR, Mourão PA. (2005). Structure and anticoagulant activity of a sulfated galactan from the red alga, Gelidium crinale. Is there a specific structural requirement for the anticoagulant action? Carbohydr Res, 340, 2015–2023.

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