Figures & data
Figure 1. Effects of TPL on the growth of K562 cells and K562/A02 cells. The cells were treated with various concentrations of TPL for 72 h, respectively. Viable cells were evaluated by MTT assay.
Figure 2. Reversal of adriamycin resistance in vitro by TPL. K562/A02 cells were incubated with 3 μg/ml of adriamycin in the presence of TPL or absence of TPL for 24 h. The rate of apoptosis was measured using flow cytometry. The cells inhibition rate was measured by MTT. A: apoptosis in K562/A02 cells; B: apoptosis in K562/A02 cells treated with TPL; C: inhibition rate; D: apoptosis rate; E: the cleavage of PARP.
Figure 3. The effect of TPL on miR-21 and PTEN expression in K562/A02 cells. A: the miR-21 levels in K562 and K562/A02 cells; B: PTEN protein expression in K562 and K562/A02 cells.
Figure 4. The effects of miR-21 on adriamycin cytotoxicity in K562 and K562/A02 cells. A: miR-21 levels in K562 cells; B: miR-21 levels in K562/A02 cells; C: cell viability of K562 cells; D: cell viability of K562/A02 cells.
Figure 5. The effects of miR-21 on PTEN protein level in K562 and K562/A02 cells. A,B: PTEN protein levels in K562 cells; C,D: PTEN protein levels in K562/A02 cells.
Figure 6. The effects of miR-21 on PTEN promoter activity in K562 cells. miR-21 markedly decreased the activity of the PTEN-3′UTR reporter.
Figure 7. The effects of PTEN on adriamycin cytotoxicity in K562 cells. A, B: PTEN protein levels in K562 cells; C: cell viability of K562 cells.
