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Research Article

Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation

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Pages 1531-1535 | Received 08 Dec 2011, Accepted 12 May 2012, Published online: 11 Sep 2012

Figures & data

Figure 1.  Structures of hesperidin and its derivatives. Hesperidin (1): a 1:1 mixture of 2 and 3; hesperetin (4): a 1:1 mixture of 5 and 6; glucosyl hesperidin (7): a 1:1 mixture of 8 and 9.

Figure 1.  Structures of hesperidin and its derivatives. Hesperidin (1): a 1:1 mixture of 2 and 3; hesperetin (4): a 1:1 mixture of 5 and 6; glucosyl hesperidin (7): a 1:1 mixture of 8 and 9.

Figure 2.   Protective effects of hesperidin (1), hesperetin (4), and glucosyl hesperidin (7) on (a) RNase A targeted by methyglyoxal (MGO) attack. (b) Advanced glycation end-products (AGEs) formation between bovine serum albumin (BSA) and glucose. The concentrations of tested samples and aminoguanidine (AG) were 1 mM. Each value was expressed as the mean ± SD, n = 3.

Figure 2.   Protective effects of hesperidin (1), hesperetin (4), and glucosyl hesperidin (7) on (a) RNase A targeted by methyglyoxal (MGO) attack. (b) Advanced glycation end-products (AGEs) formation between bovine serum albumin (BSA) and glucose. The concentrations of tested samples and aminoguanidine (AG) were 1 mM. Each value was expressed as the mean ± SD, n = 3.

Figure 3.   Protective effects of hesperidin (1), (2S)-hesperidin (2), and (2R)-hesperidin (3) on (a) RNase A targeted by methyglyoxal (MGO) attack. (b) Advanced glycation end-products (AGEs) formation between bovine serum albumin (BSA) and glucose. The concentrations of tested samples and aminoguanidine (AG) were 1 mM. Each value was expressed as the mean ± SD, n = 3.

Figure 3.   Protective effects of hesperidin (1), (2S)-hesperidin (2), and (2R)-hesperidin (3) on (a) RNase A targeted by methyglyoxal (MGO) attack. (b) Advanced glycation end-products (AGEs) formation between bovine serum albumin (BSA) and glucose. The concentrations of tested samples and aminoguanidine (AG) were 1 mM. Each value was expressed as the mean ± SD, n = 3.

Figure 4.  Protective effects of hesperetin (4), (2S)-hesperetin (5), and (2R)-hesperetin (6) on (a) RNase A targeted by methyglyoxal (MGO) attack. (b) Advanced glycation end-product (AGE) formation between bovine serum albumin (BSA) and glucose. The concentrations of tested samples and aminoguanidine (AG) were 1 mM. Each value was expressed as the mean ± SD, n = 3.

Figure 4.  Protective effects of hesperetin (4), (2S)-hesperetin (5), and (2R)-hesperetin (6) on (a) RNase A targeted by methyglyoxal (MGO) attack. (b) Advanced glycation end-product (AGE) formation between bovine serum albumin (BSA) and glucose. The concentrations of tested samples and aminoguanidine (AG) were 1 mM. Each value was expressed as the mean ± SD, n = 3.

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