Figures & data
Table 1. Effect of PESA and α-amyrin acetate on glucose levels in STZ-induced diabetic rats.
Table 2. Effect of PESA and α-amyrin acetate on serum biomarkers in STZ-induced diabetic rats after treatment.
Table 3. Effect of PESA and α-amyrin acetate on serum lipid profiles in STZ-induced diabetic rats after treatment.
Table 4. Effect of PESA and α-amyrin acetate on serum insulin, glycosylated hemoglobin (HbA1c) of STZ treated diabetic rats.
Figure 2. Photomicrographs of 15 day experimental rat liver. Section A (10×) shows a normal histological section with well arranged cells and clear large central vein, cytoplasm and nucleus are well preserved. Section B (10×) shows the complete destruction of hepatocytes degeneration of central vein, fatty degeneration, loss of cell structure and damage in cell membrane in STZ-induced diabetic rat liver. Sections C, D, and E (10×) are treated with PESA (100, 250 & 500 mg/kg) and shows slight necrosis and restored to normal, respectively. Picture F, G & H (10×) depicts no damage and the hepatocyte architecture is near to normal by treatment with α-amyrin acetate (25, 50 & 75 mg/kg). These depict the well preserved hepatocytes, clear cytoplasm and nucleus with less neutrophil infiltration. In case of standard glibenclamide (0.5 mg/kg), I (10×) treatment shows no damage in the hepatocytes and well arranged with central vein.
![Figure 2. Photomicrographs of 15 day experimental rat liver. Section A (10×) shows a normal histological section with well arranged cells and clear large central vein, cytoplasm and nucleus are well preserved. Section B (10×) shows the complete destruction of hepatocytes degeneration of central vein, fatty degeneration, loss of cell structure and damage in cell membrane in STZ-induced diabetic rat liver. Sections C, D, and E (10×) are treated with PESA (100, 250 & 500 mg/kg) and shows slight necrosis and restored to normal, respectively. Picture F, G & H (10×) depicts no damage and the hepatocyte architecture is near to normal by treatment with α-amyrin acetate (25, 50 & 75 mg/kg). These depict the well preserved hepatocytes, clear cytoplasm and nucleus with less neutrophil infiltration. In case of standard glibenclamide (0.5 mg/kg), I (10×) treatment shows no damage in the hepatocytes and well arranged with central vein.](/cms/asset/f670f717-9008-4b87-9369-421bf42b04ae/iphb_a_730531_f0002_b.gif)