Figures & data
Figure 1. Structures of compounds 1 and 2.
Figure 2. Effect of 1,2,3-trimethoxy-5-oxonoraporphine and ouregidione on cell proliferation of K562, U937, and HL-60 cells. Human leukemic cell lines (1 × 104 cells/well) were incubated with ouregidione (0–100 μg/mL) for (A) 48 and (B) 72 h or 1,2,3-trimethoxy-5-oxonoraporphine (0–100 μg/mL) for (C) 48 and (D) 72 h. Inhibition of cell proliferation was determined by the MTT reduction assay after the specified incubation periods. The data represent the mean ± SD of three independent experiments. Sample groups were significantly different from the control group. *P < 0.05.
Figure 3. Effect of 1,2,3-trimethoxy-5-oxonoraporphine and ouregidione on cell distribution of human leukemic cell lines. (A) HL-60, (B) U937, and (C) K562 cells (1 × 105 cells/well) were incubated with ouregidione and 1,2,3-trimethoxy-5-oxonoraporphine at 100 μg/mL for 48 h. The cell cycle was analyzed by flow cytometry after propidium iodide (PI) staining. Percentages of cells in G1, S, and G2/M phase are presented. The data represent the mean ± SD of three independent experiments. Sample groups were significantly different from the control group. *P < 0.05.
