Corchorus olitorius (jute) extract induced cytotoxicity and genotoxicity on human multiple myeloma cells (ARH-77)

Figures & data

Figure 1. Evaluation of comet results (×400). Nuclei were scored as 0, 1+, 2+, 3+ and 4+ according to apparent relative proportion of DNA in the tail and head. Arbitrary units (AU) for quantification were obtained by multiplying counted nuclei by their score.

Table 1. TPC, IC₅₀ of DPPH• scavenging activity, and IC₅₀ of cytotoxicity.

Extracts	TPC (mg GAE*/g extract)	IC50 (FRSA) (µg/mL)	IC50 (cytotoxicty) (µg/mL)
Leaf	78.1 ± 1.0	22.7 ± 1.8	150.6 ± 0.9
Seed	2.2 ± 0.5	1040.8 ± 11.0	17.0 ± 1.1

GAE, gallic acid equivalents.

All values significantly differ between leaf and seed extracts (p < 0.05).

Figure 2. Effect of LE and SE on ARH-77 cell viability. SEM were obtained from three replicate plates.

Figure 3. Genotoxic damage induced by LE and SE. *Significant differences between control and other treatment groups. p Values represent significant difference between 1/2 IC₅₀ and IC₅₀ LE and SE treatment groups.