Figures & data
Figure 1. Gastric mucosal injury index in rats after pretreatment with rutin (50, 100 or 200 mg/kg) 60 min before I/R procedure. The presence of lesions was established at postmortem by visual inspection of the stomach. Vehicle or different doses of drugs were administered for five consecutive days before gastric mucosal injury. Data are the mean ± SEM for 6–8 animals. ***p < 0.001 compared with the sham group; #p < 0.05, ##p < 0.01, ###p < 0.001 compared with the I/R control.
Figure 2. Effects of rutin on histological findings of gastric damage induced by I/R in rats after HE stain: sham (A), I/R control (B), rutin (200 mg/kg) (C). Rutin was given by gavage 60 min before the experiment.
Figure 3. Effects of different doses of rutin on the MPO activity in the gastric mucosal after I/R in rats. Animals were all subjected to 30 min ischemia and 1 h reperfusion. Vehicle or different doses of drugs were administered for five consecutive days before gastric mucosal injury. Data are the mean ± SEM for six to eight animals. ***p < 0.001 compared with the sham group; ##p < 0.01, ###p < 0.001 compared with the I/R control.
Figure 4. Effect of different doses of rutin on MDA content in the gastric mucosal after I/R in rats. Animals were all subjected to 30 min ischemia and 1 h reperfusion. Vehicle or different doses of drugs were administered for five consecutive days before gastric mucosal injury. ***p < 0.001 compared with the sham group; #p < 0.05, ##p < 0.01, ###p < 0.001 compared with the I/R control.
Table 1. Effects of different doses of rutin on changes in the activities of cNOS and iNOS in the gastric mucosa of rats subjected to I/R.
