Figures & data
Table 1. Precision and accuracy data for ISL in plasma and tissues (n = 6).
Figure 2. Mean plasma concentration–time profiles of ISL after intravenous administration at doses of 10 mg/kg (n = 6), 20 mg/kg (n = 6) and 50 mg/kg (n = 6) in rats. Vertical bars represent SD.
![Figure 2. Mean plasma concentration–time profiles of ISL after intravenous administration at doses of 10 mg/kg (n = 6), 20 mg/kg (n = 6) and 50 mg/kg (n = 6) in rats. Vertical bars represent SD.](/cms/asset/08d10f27-3bc3-48f7-bd39-827d84fc867c/iphb_a_832334_f0002_b.jpg)
Figure 3. Relationship between Cmax and AUC versus dose in rats receiving single 10, 20 and 50 mg/kg intravenous doses of ISL.
![Figure 3. Relationship between Cmax and AUC versus dose in rats receiving single 10, 20 and 50 mg/kg intravenous doses of ISL.](/cms/asset/608b7e40-3ff6-401e-8e4c-72b295ed8e5b/iphb_a_832334_f0003_b.jpg)
Table 2. The main pharmacokinetic parameters of ISL after single intravenous administration at different doses in rats.
Figure 4. Mean plasma concentration–time profiles of ISL after oral administration at doses of 20 mg/kg (n = 6), 50 mg/kg (n = 6) and 100 mg/kg (n = 6) in rats. Vertical bars represent SD.
![Figure 4. Mean plasma concentration–time profiles of ISL after oral administration at doses of 20 mg/kg (n = 6), 50 mg/kg (n = 6) and 100 mg/kg (n = 6) in rats. Vertical bars represent SD.](/cms/asset/827f1dea-fecf-4c3c-a539-c698923883bf/iphb_a_832334_f0004_b.jpg)
Table 3. The main pharmacokinetic parameters of ISL after single oral administration at different doses in rats.
Figure 5. Concentration of ISL in tissues after single intravenous administration (A) and oral administration (B) to mice at 20 mg/kg doses.
![Figure 5. Concentration of ISL in tissues after single intravenous administration (A) and oral administration (B) to mice at 20 mg/kg doses.](/cms/asset/d8fa595d-62fe-48d0-ac50-731b2e92deea/iphb_a_832334_f0005_b.jpg)
Table 4. Non-compartmental pharmacokinetic parameters of ISL in mice following a single intravenous dose of 20 mg/kg.
Table 5. Non-compartmental pharmacokinetic parameters of ISL in mice following a single oral dose of 20 mg/kg.