Effects of Alismatis rhizome on rat cytochrome P450 enzymes

Figures & data

Figure 1. Mean plasma concentration–time curves of phenacetin in rats.

Table 1. Main pharmacokinetic parameters of phenacetin after multiple doses of RA in rat plasma (n = 6, mean ± SD).

Parameter	BCG	LDG	MDG	HDG
t1/2 (h)	6.307 ± 0.455	5.699 ± 0.568	5.305 ± 0.740*	5.094 ± 0.378*
Tmax(h)	0.264 ± 0.005	0.252 ± 0.002	0.246 ± 0.004	0.235 ± 0.005*
Cmax (ng/mL)	4071.978 ± 231.772	3860.549 ± 183.125	3644.780 ± 165.036*	3444.857 ± 115.921*
AUC(0–∞) (µg·h/L)	22 720.318 ± 375.609	20 847.194 ± 518.087	16 573.163 ± 508.729*	14 414.784 ± 458.188**
MRT(0–∞) (h)	8.237 ± 0.386	7.878 ± 0.568	6.986 ± 0.868*	6.746 ± 0.459*
CL (L/h/kg)	0.980 ± 0.015	1.063 ± 0.046	1.209 ± 0.054*	1.389 ± 0.044**

*Significantly different from control, p < 0.05. **Significantly different from control, p < 0.01.

Figure 2. Mean plasma concentration–time curves of tolbutamide in rats.

Table 2. Main pharmacokinetic parameters of tolbutamide after multiple doses of RA in rat plasma (n = 6, mean ± SD).

Parameter	BCG	LDG	MDG	HDG
t1/2 (h)	6.025 ± 0.525	5.973 ± 0.624	5.703 ± 0.914	5.913 ± 0.800
Tmax(h)	2.529 ± 0.189	2.571 ± 0.535	2.602 ± 0.454	2.486 ± 0.488
Cmax (ng/mL)	16 550.573 ± 433.216	16 312.249 ± 363.386	16 749.571 ± 247.383	16 346.857 ± 262.406
AUC(0–∞) (µg·h/L)	186 920.019 ± 2039.827	193 030.113 ± 2715.062	189 093.764 ± 2173.525	188 684.453 ± 2525.788
MRT(0–∞) (h)	9.699 ± 1.914	9.637 ± 1.536	9.676 ± 1.065	9.640 ± 1.052
CL (L/h/kg)	0.027 ± 0.003	0.026 ± 0.004	0.027 ± 0.002	0.026 ± 0.002

Figure 3. Mean plasma concentration–time curves of chlorzoxazone in rats.

Table 3. Main pharmacokinetic parameters of chlorzoxazone after multiple doses of RA in rat plasma (n = 6, mean ± SD).

Parameter	BCG	LDG	MDG	HDG
t1/2 (h)	4.819 ± 0.159	4.670 ± 0.156	4.798 ± 0.117	4.689 ± 0.144
Tmax (h)	3.101 ± 0.298	3.043 ± 0.434	2.987 ± 0.278	3.143 ± 0.378
Cmax (ng/mL)	9940.143 ± 155.694	9809.714 ± 170.832	9777.571 ± 168.588	9750.857 ± 164.919
AUC(0–∞) (µg·h/L)	90 333.422 ± 1480.638	88 338.849 ± 1520.275	89 129.107 ± 1261.451	90 609.608 ± 1748.562
MRT(0–∞) (h)	7.759 ± 0.208	7.520 ± 0.168	7.671 ± 0.148	7.797 ± 0.199
CL (L/h/kg)	0.219 ± 0.004	0.217 ± 0.001	0.218 ± 0.004	0.217 ± 0.004

Figure 4. Mean plasma concentration–time curves of midazolam in rats.

Table 4. Main pharmacokinetic parameters of midazolam after multiple doses of RA in rat plasma (n = 6, mean ± SD).

Parameter	BCG	LDG	MDG	HDG
t1/2 (h)	5.365 ± 0.191	5.717 ± 0.250	5.739 ± 0.168	6.728 ± 0.207*
Tmax(h)	0.247 ± 0.004	0.266 ± 0.005	0.274 ± 0.005	0.298 ± 0.004*
Cmax (ng/mL)	6256.714 ± 127.088	6554.429 ± 152.446	6768.429 ± 149.608	7063.143 ± 182.872*
AUC(0–∞) (µg·h/L)	39 312.245 ± 1602.686	44 292.342 ± 1159.704*	51 103.299 ± 2184.750*	62 943.242 ± 2433.412**
MRT(0–∞) (h)	7.464 ± 0.588	8.024 ± 0.652	8.246 ± 0.927*	9.686 ± 0.637*
CL (L/h/kg)	0.254 ± 0.004	0.226 ± 0.006*	0.196 ± 0.003*	0.159 ± 0.003**

*Significantly different from control, p < 0.05. **Significantly different from control, p < 0.01.