Antihyperglycemic and antihyperlipidemic effects of Salvadora persica in streptozotocin-induced diabetic rats

Figures & data

Table 1. Effect of the root-HA of S. persica on oral glucose tolerance test in normal rats (OGTT).

		Plasma glucose concentration (mg/dL) in min
Group	Treatment	30	60	120
1	Control glucose (2 g/kg)	180.50 ± 0.64	150.00 ± 0.40	135.25 ± 0.47
2	Root-HA (200 mg/kg)	167.50 ± 0.64	136.50 ± 0.64*	120.25 ± 0.47*
3	Root-HA (400 mg/kg)	156.00 ± 0.40*	115.50 ± 0.64*	95.00 ± 0.40*
4	Glibenclamide (5 mg/kg)	150.00 ± 0.40*	101.50 ± 0.64*	72.50 ± 0.64*

Values are expressed in terms of mean ± SEM, n = 6 in each group. Root-HA, S. persica hydroalcoholic extract root; GT, glibenclamide treated. Results of test and standard were compared with the control group.

*p < 0.05.

Table 2. Effect of the root-HA of S. persica on blood glucose level in STZ-induced in diabetic rats.

		Blood glucose (mg/dL) in day
Group	Treatment	0	7	14	21
1	Normal control (−)	93.25 ± 1.10	93.00 ± 0.91	93.00 ± 1.47	92.50 ± 1.19
2	Diabetic control (−)	281.25 ± 1.65	292.25 ± 2.05	305.00 ± 2.27	323.25 ± 1.88
3	Diabetic rats + root-HA (400 mg/kg)	285.50 ± 1.32	261.75 ± 1.25*	209.25 ± 1.54*	150.25 ± 2.28*
4	Diabetic rats + glibenclamide (5 mg/kg)	281.50 ± 2.90	246.50 ± 2.90*	178.00 ± 2.04**	106.00 ± 1.95**

Values are expressed in terms of mean ± SEM, n = 6 in each group. Root-HA, S. persica hydroalcoholic extract root; GT, glibenclamide treated. Results of test and standard were compared with the diabetic control group.

*p < 0.05, **p < 0.01.

Table 3. Effect of the root-HA of S. persica on lipid profile in STZ-induced diabetic rats.

		Lipid profile in STZ-induced diabetic rats (mg/dL)
Group	Treatment	TC	TG	HDL	LDL	VLDL
1	Normal control	83.25 ± 1.10	74.50 ± 0.64	28.50 ± 0.64	44.75 ± 1.10	17.50 ± 0.64
2	Diabetic control	173.25 ± 1.88	133.25 ± 1.49	18.50 ± 0.64	129.75 ± 1.93	34.75 ± 1.49
3	Root-HA (400 mg/kg)	102.75 ± 1.93*	91.50 ± 1.55*	26.50 ± 0.64*	53.00 ± 1.29*	19.00 ± 0.40*
4	Glibenclamide	75.25 ± 1.10**	61.50 ± 1.04*	29.50 ± 0.64*	46.50 ± 0.64*	16.50 ± 0.47**

Values are expressed in terms of mean ± SEM, n = 6 in each group. Root-HA, S. persica hydroalcoholic extract root; GT, glibenclamide treated. Results of test and standard were compared with the diabetic control group.

*p < 0.05, **p < 0.01.

Table 4. Effect of the root-HA of S. persica on body weight in diabetic rats.

		Changes in body weight (g) in day
Group	Treatment	0	7	14
1	Normal control	220.50 ± 0.64	234.00 ± 0.40	247.25 ± 0.47
2	Diabetic control	218.25 ± 0.47	207.25 ± 0.47	198.25 ± 0.85
3	Root-HA (400 mg/kg)	218.25 ± 0.85	209.25 ± 0.85	217.00 ± 0.81*
4	Glibenclamide	215.50 ± 0.64	208.50 ± 0.64	217.75 ± 0.47*

Values are expressed in terms of mean ± SEM, n = 6 in each group. Root-HA, Salvadora persica hydroalcoholic extract root; GT, glibenclamide treated. Results of test and standard were compared with the diabetic control group.

*p < 0.05.