Recent progress in Glinus oppositifolius research

Figures & data

Table 1. Ethnobotanical uses of G. oppositifolius found worldwide.

Sl. No.	Regions	Traditional use	Pharmacological activity	Extract/constituents evaluated	Reference
1.	Mali	Wound healing	Immunomodulating activities	Hot water extract aerial parts	Debes (1998)
2.	Mali	Malaria	Immunomodulating activities	Decoction of aerial parts	Diallo et al. (1999)
3.	Mali	Joint pains, inflammations, diarrhoea, intestinal parasites, fever, boils and skin disorders	Immunomodulating activities	Aqueous extract aerial parts/triterpenoid saponins	Diallo (2000)
4.	Mali	Malaria, fever and jaundice	Antiprotozoal activity Antimalarial activity	Chloroform extract aerial parts/triterpenoid saponins, glinoside	Traore et al. (2000)
5.	Mali	Malaria, wound healing and hepatitis	Antifungal activity Latvicidal activity Molusscicidal activity Antioxidant activity Radical scavenging activity	Methanol, dichloromethane, 25% ethanol and aqueous extract whole plant/ triterpenoid saponins	Diallo (2001)
6.	Mali	Joint pains, inflammations, fever, malaria and wounds	Immunomodulating activities	50 °C water extract aerial parts/polysaccharides	Inngjerdingen et al. (2005)
7.	Mali	Joint pains, inflammations, fever, malaria and wounds	Immunomodulating activities	50 °C water extract aerial parts/polysaccharides	Inngjerdingen et al. (2007a,b)
8.	India	Stomachic, uterine stimulant, aperient, lochia, earache, itch and skin diseases	Free radical scavenging activity Antioxidant activity	70% Ethanol extract whole plant	Asok Kumar et al. (2009)
9.	Thailand	Expectorant and antipyretic	–	Aqueous extract whole plant/amino acid derivative, flavonoid glycosides, nucleoside	Sahakitpichan et al. (2010)
10.	India	Skin disease, increase appetite, cures vata, kapha, piles, leucoderma, tonic to intestine, urinary infections, fever, cough and liver problem	Antihyperglycemic activity Antihyperlipidemic activity Antioxidant activity	Methanol and aqueous extract	Behera et al. (2010)
11.	India	Antiseptic and antidermatitic, earache, itch, skin diseases, stomachic, uterine stimulant, aperients and lochia	Hepatoprotective effect	Methanol extract root	Natarajan et al. (2010)
12.	India	Diuretic, anthelmintic, digestive, antimalarial and antiviral property	Antimicrobial activity Anthelmintic activity	Petroleum ether, chloroform and methanol extract aerial parts	Pattanayak et al. (2011)
13.	Bangladesh	Joint pain, inflammation, diarrhea, fever, boils and skin disorders	Analgesic activity Anti-inflammatory activity	Methanol extract leaves	Hoque et al. (2011a)
14.	Bangladesh	Jaundice, abdominal pain, malaria, wound	Antihyperglycemic activity Antioxidant activity	Methanol extract leaves	Hoque et al. (2011b)
15.	India	Skin disease, increase appetite, cures kapha, piles, leucoderma, tonic to intestine, urinary infections, fever, cough, liver problem	Antihyperglycaemic activity	80% Ethanol extract aerial parts	Sahu et al. (2012)
16.	India	Expectorant, antipyretic, jaundice and abdominal pain	Antihyperglycemic activity Antihyperlipidemic activity	Methanol extract	Panigrahi et al. (2012)
17.	India	Skin diseases	α-Glucosidase inhibitory activity	Methanol extract aerial parts/triterpene saponins	Kumar et al. (2013)

Figure 1. Chemical structures of typical constituents isolated from G. oppositifolius.

Debes SC. (1998) En medisinplante fra Mali, Glinus oppositifolius. [Master’s Thesis]. School of Pharmacy, University of Oslo, Norway

 Google Scholar

Diallo D, Hveem B, Mahmoud MA, et al. (1999). An ethnobotanical survey of herbal drugs of Gourma district. Mali Pharmaceutical Biol 37:80–91

 Web of Science ®Google Scholar

Diallo D. (2000) Ethnopharmacological survey of medicinal plants in Mali and phytochemical study of four of them: Glinus oppositifolius (Aizoaceae), Diospyros abyssinica (Ebenaceae), Entada Africana (Mimosaceae), Trichilia emetica (Meliaceae). These de Doctorat. Faculte des Sciences, Universite de Lausanne, Switzerland

 Google Scholar

Traore F, Faure R, Ollivier E, et al. (2000). Structure and antiprotozoal activity of triterpenoid saponins from Glinus oppositifolius. Planta Med 66:368–71

 PubMed Web of Science ®Google Scholar

Diallo D, Marston A, Terreaux C, et al. (2001). Screening of Malian plants for antifungal, latvicidal, molusscicidal, antioxidant and radical scavenging activities. Phytother Res 15:401–6

 PubMed Web of Science ®Google Scholar

Inngjerdingen KT, Debes SC, Inngjerdingen M, et al. (2005). Bioactive pectic polysaccharides from Glinus oppositifolius (L.) Aug. DC., a Malian medicinal plant, isolation and partial characterization. J Ethnopharmacol 101:204–14

 PubMed Web of Science ®Google Scholar

Asok Kumar K, Uma Maheswari M, Sivashanmugam AT, et al. (2009). Free radical scavenging and antioxidant activities of Glinus oppositifolius (carpet weed) using different in vitro assay systems. Pharm Biol 47:474–82

 Web of Science ®Google Scholar

Sahakitpichan P, Disadee W, Ruchirawat S, Kanchanapoom T. (2010). l-(−)-(N-trans-Cinnamoyl)-arginine, an acylamino acid from Glinus oppositifolius (L.) Aug. DC. Molecules 15:6186–92

 PubMed Web of Science ®Google Scholar

Behera GM, Satish Kumar BN, Malay Baidya M, Panigrahi G. (2010). Antihyperglycemic, antihyperlipidemic and antioxidant activity of Glinus oppositifolius (L.) Aug. DC. Pharmacologyonline 3:915–36

 Google Scholar

Natarajan P, Thanga Thirupathi A, Raja Sekharan T, et al. (2010). Hepatoprotective effect of Glinus oppositifolius Linn. Res J Pharmacol Pharmacodyn 2:289–92

 Google Scholar

Pattanayak S, Nayak SS, Dinda SC, et al. (2011). Antimicrobial and anthelmintic potential of Glinus oppositifolius (Linn) family: Molluginaceae. Pharmacologyonline 1:165–9

 Google Scholar

Hoque N, Habib R, Imam MZ, et al. (2011a). Analgesic and anti-inflammatory potential of methanol extract of Glinus oppositifolius L. Aust J Basic Appl Sci 5:729–33

 Google Scholar

Hoque N, Imam MZ, Akter S, et al. (2011b). Antioxidant and antihyperglycemic activities of methanol extract of Glinus oppositifolius leaves. J Appl Pharm Sci 1:50–3

 Google Scholar

Sahu SK, Das D, Tripathy NK, et al. (2012). Evaluation of hypoglycemic activity of Mollugo pentaphylla and Glinus oppositifolius (L). Rasayan J Chem 5:57–62

 Google Scholar

Panigrahi G, Mishra US, Mahapatra S, et al. (2012). Hypoglycemic and hypolipidemic activities of methanol extract of Glinus oppositifolius. Int J Pharm 2:491–7

 Google Scholar

Kumar D, Shah V, Ghosh R, Pal BC. (2013). A new triterpenoid saponin from Glinus oppositifolius with α-glucosidase inhibitory activity. Nat Prod Res 27:624–9

 PubMed Web of Science ®Google Scholar