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Original Article

Alteration of pentylenetetrazole-induced seizure threshold by chronic administration of ginger (Zingiber officinale) extract in male mice

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Pages 752-757 | Received 12 Mar 2014, Accepted 02 Jul 2014, Published online: 22 Jan 2015

Figures & data

Figure 1. The effect of different doses of ginger (25–100 mg/kg) on the threshold for the first myoclonic twitch in the i.v. PTZ seizure threshold test in mice. Data are presented as mean ± SEM of six mice in each group. One-way ANOVA followed by the Tukey's post hoc multiple comparison test was used to analyze the data (PB, phenobarbital; ZOE: Zingiber officinale extract). ***p < 0.001 versus vehicle control (saline).

Figure 1. The effect of different doses of ginger (25–100 mg/kg) on the threshold for the first myoclonic twitch in the i.v. PTZ seizure threshold test in mice. Data are presented as mean ± SEM of six mice in each group. One-way ANOVA followed by the Tukey's post hoc multiple comparison test was used to analyze the data (PB, phenobarbital; ZOE: Zingiber officinale extract). ***p < 0.001 versus vehicle control (saline).

Figure 2. The effect of different doses of ginger (25–100 mg/kg) on the threshold for the generalized clonic seizures in the i.v. PTZ seizure threshold test in mice. Data are presented as mean ± SEM of six mice in each group. One-way ANOVA followed by the Tukey's post hoc multiple comparison test was used to analyze the data (PB, phenobarbital; ZOE: Zingiber officinale extract). **p < 0.05 and ***p < 0.001 versus vehicle control (saline).

Figure 2. The effect of different doses of ginger (25–100 mg/kg) on the threshold for the generalized clonic seizures in the i.v. PTZ seizure threshold test in mice. Data are presented as mean ± SEM of six mice in each group. One-way ANOVA followed by the Tukey's post hoc multiple comparison test was used to analyze the data (PB, phenobarbital; ZOE: Zingiber officinale extract). **p < 0.05 and ***p < 0.001 versus vehicle control (saline).

Figure 3. The effect of different doses of ginger (25–100 mg/kg) on the threshold for the forelimb/hindlimbs tonic extension in the i.v. PTZ seizure threshold test in mice. Data are presented as mean ± SEM of six mice in each group. One-way ANOVA followed by the Tukey's post hoc multiple comparison test was used to analyze the data (PB, phenobarbital; ZOE: Zingiber officinale extract). *p < 0.05 and **p < 0.01 versus vehicle control (saline).

Figure 3. The effect of different doses of ginger (25–100 mg/kg) on the threshold for the forelimb/hindlimbs tonic extension in the i.v. PTZ seizure threshold test in mice. Data are presented as mean ± SEM of six mice in each group. One-way ANOVA followed by the Tukey's post hoc multiple comparison test was used to analyze the data (PB, phenobarbital; ZOE: Zingiber officinale extract). *p < 0.05 and **p < 0.01 versus vehicle control (saline).

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