Figures & data
Figure 1. Chemical structures of natural and synthetic compounds derived from Salvia miltiorrhiza.
Figure 2. Schematic overview of some neuroprotective pathways of Salvia miltiorrhiza. STC inhibit Aβ aggregation and amyloid plaques formation; Cts increases α-secretase activity and promotes sAPPα generation; Tan IIA decreases tau phosphorylation via calcium and p35/cdk5 pathways; Sal A, Sal B, SBE, Tan IIA, and Danshensu exhibit neuroprotective effects against oxidative injury via multiple pathways and decrease apoptosis. Aβ, amyloid-β; STC, salvianolic acid A salvianolic acid B, tanshinone I, tanshinone IIA, and cryptotanshinone; Cts, cryptotanshinone; Tan IIA, tanshinone IIA; Sal A, salvianolic acid A; Sal B, salvianolic acid B; SBE, salvianic borneol ester.
