Figures & data
Figure 1. Structures of C-geranylated flavanones (1–6) from P. tomentosa fruits and epigallocatechin gallate (7) used for bio-activity testing.
Table 1. Leishmania species were treated 72 h with concentrations ranging from 0.25 to 125 μM of compounds 1–6 obtained from Paulownia tomentosa and with miltefosine as a control.
Figure 2. Apoptogenic effect of compounds 1 and 2 on L. donovani promastogote cells. Percentage of cells in apoptosis calculated from flow cytometry data. Experiments were run in independent duplicates.
Table 2. MIC values (μg/mL/μM) of 1–6.
Table 3. MIC and MBC values (μg/mL) of compound 3 or 5, ∑FIC and resultant effect of combination with OXA against various strains of MRSA and MRSI.
Table 4. MIC and MBC values (μg/mL) of compound 3 or 5, ∑FIC and resultant effect of combination with TTC against various strains of MRSA and MRSI.
Table 5. MIC and MBC values (μg/mL) of compound 3 or 5, ∑FIC and resultant effect of combination with CIP against various strains of MRSA.
Table 6. MIC and MBC values (μg/mL) of compound 7, ∑FIC and resultant effect of combination with TTC or OXA against various strains of MRSA.