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Research Article

In vitro antiproliferative activity of uncommon xanthones from branches of Garcinia achachairu

Luisa Nathália Bolda MarianoPrograma de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, Brazil;

Débora Barbosa Vendramini-CostaCentro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA) – Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil;

Ana Lúcia Tasca Gois RuizCentro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA) – Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil;

João Ernesto de CarvalhoCentro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA) – Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil; ;Faculdade de Ciências Farmacêuticas – Universidade Estadual de Campinas (UNICAMP), Campinas, Campinas, São Paulo, Brazil

Rogério CorrêaPrograma de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, Brazil;

Valdir Cechinel FilhoPrograma de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, Brazil;

Franco Delle MonachePrograma de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, Brazil;

Rivaldo NieroPrograma de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, Brazil; Correspondence[email protected]

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Figures & data

Table 1. ¹H and ¹³C NMR spectroscopic data of 1 at 300 MHz (for ¹H NMR) and 75 MHz (for ¹³C NMR) in CDCl₃, δ in ppm, J (in parenthesis) in Hz.

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Figure 1. Molecular structure of compounds isolated of from branches of G. achachairu.

Figure 2. Significant long-range correlations observed in ¹³C–¹H HMBC for compound 1 (A) and 2 (B) isolated from branches of G. achachairu.

Figure 2. Significant long-range correlations observed in 13C–1H HMBC for compound 1 (A) and 2 (B) isolated from branches of G. achachairu.

Table 2. ¹H and ¹³C NMR spectroscopic data of 2 at 300 MHz (for ¹H NMR) and 75 MHz (for ¹³C NMR) in CDCl₃, δ in ppm, J (in parenthesis) in Hz.

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Table 3. Antiproliferative activity of methanolic extract, fractions and pure compounds from branches of G. achachairu, against human cancer cell linesTable Footnote^a (TGI (μg/mL)Table Footnote^b).

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Table 4. Descriptors involved in ADMET evaluation.

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In vitro antiproliferative activity of uncommon xanthones from branches of Garcinia achachairu

Table 1. ¹H and ¹³C NMR spectroscopic data of 1 at 300 MHz (for ¹H NMR) and 75 MHz (for ¹³C NMR) in CDCl₃, δ in ppm, J (in parenthesis) in Hz.

Table 2. ¹H and ¹³C NMR spectroscopic data of 2 at 300 MHz (for ¹H NMR) and 75 MHz (for ¹³C NMR) in CDCl₃, δ in ppm, J (in parenthesis) in Hz.

Table 3. Antiproliferative activity of methanolic extract, fractions and pure compounds from branches of G. achachairu, against human cancer cell linesTable Footnote^a (TGI (μg/mL)Table Footnote^b).

Table 4. Descriptors involved in ADMET evaluation.

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In vitro antiproliferative activity of uncommon xanthones from branches of Garcinia achachairu

Figures & data

Table 1. 1H and 13C NMR spectroscopic data of 1 at 300 MHz (for 1H NMR) and 75 MHz (for 13C NMR) in CDCl3, δ in ppm, J (in parenthesis) in Hz.

Table 2. 1H and 13C NMR spectroscopic data of 2 at 300 MHz (for 1H NMR) and 75 MHz (for 13C NMR) in CDCl3, δ in ppm, J (in parenthesis) in Hz.

Table 3. Antiproliferative activity of methanolic extract, fractions and pure compounds from branches of G. achachairu, against human cancer cell linesTable Footnotea (TGI (μg/mL)Table Footnoteb).

Table 4. Descriptors involved in ADMET evaluation.

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Table 1. ¹H and ¹³C NMR spectroscopic data of 1 at 300 MHz (for ¹H NMR) and 75 MHz (for ¹³C NMR) in CDCl₃, δ in ppm, J (in parenthesis) in Hz.

Table 2. ¹H and ¹³C NMR spectroscopic data of 2 at 300 MHz (for ¹H NMR) and 75 MHz (for ¹³C NMR) in CDCl₃, δ in ppm, J (in parenthesis) in Hz.

Table 3. Antiproliferative activity of methanolic extract, fractions and pure compounds from branches of G. achachairu, against human cancer cell linesTable Footnote^a (TGI (μg/mL)Table Footnote^b).