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Research Article

Assessment of the antidiarrhoeal properties of the aqueous extract and its soluble fractions of Chebulae Fructus (Terminalia chebula fruits)

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Pages 1847-1856 | Received 31 Jul 2015, Accepted 10 Dec 2015, Published online: 26 Feb 2016

Figures & data

Table 1. Effect of the CFAE on castor oil-induced diarrhoea in mice.

Table 2. Effect of the CFAE on gastrointestinal motility in mice.

Table 3. Effect of the CFAE on castor oil-induced enteropooling in rats.

Figure 1. Small intestine sections of mice treated with PSS + castor oil (A), CFAE + castor oil (B) and PSS + PSS (C).

Figure 1. Small intestine sections of mice treated with PSS + castor oil (A), CFAE + castor oil (B) and PSS + PSS (C).

Figure 2. Liver sections of mice treated with PSS + castor oil (A), CFAE + castor oil (B) and PSS + PSS (C).

Figure 2. Liver sections of mice treated with PSS + castor oil (A), CFAE + castor oil (B) and PSS + PSS (C).

Table 4. Effect of the CFAE on castor oil-induced diarrhoea in mice.

Figure 3. The MS spectra of four representative compounds in the ethyl acetate fraction of CFAE: (1A and 1B) gallic acid; (2A and 2B) 3,4,6-tri-O-galloyl-β-d-Glc; (3A and 3B) corilagin; (4A and 4B) ellagic acid.

Figure 3. The MS spectra of four representative compounds in the ethyl acetate fraction of CFAE: (1A and 1B) gallic acid; (2A and 2B) 3,4,6-tri-O-galloyl-β-d-Glc; (3A and 3B) corilagin; (4A and 4B) ellagic acid.

Figure 4. Representative HPLC chromatograms of (A) the ethyl acetate fraction of the CFAE; (B) mixed standard solutions. (1) Gallic acid; (2) 3,4,6-tri-O-galloyl-β-d-Glc; (3) corilagin; (5) ellagic acid. The HPLC analytical conditions were described in the Analysis of the main compounds in ethyl acetate fraction section.

Figure 4. Representative HPLC chromatograms of (A) the ethyl acetate fraction of the CFAE; (B) mixed standard solutions. (1) Gallic acid; (2) 3,4,6-tri-O-galloyl-β-d-Glc; (3) corilagin; (5) ellagic acid. The HPLC analytical conditions were described in the Analysis of the main compounds in ethyl acetate fraction section.

Table 5. HPLC-ESI-MS fragmentation (negative and positive ion modes) and UV–vis absorption data of the compounds detected in the ethyl acetate fraction of the CFAE.

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