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Research Article

Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis

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Pages 1891-1900 | Received 20 Jul 2015, Accepted 26 Dec 2015, Published online: 03 Feb 2016

Figures & data

Table 1. Content of polyphenolic compounds in yellow tea extract (mg/g).

Table 2. Effect of yellow tea extract on plasma clinical chemistry parameters in rats given NDEA.

Figure 1. Representative images (×100) of liver sections (haematoxylin and eosin staining). I Control rat. Normal liver architecture. Representative images (×100) of liver sections (haematoxylin and eosin staining). II Rat treated with yellow tea alone. Normal liver structure. Representative images (×100) of liver sections (haematoxylin and eosin staining). III Rat treated with NDEA alone. Pathological liver structure: (A) dysplastic nodule or early hepatocellular carcinoma. Representative images (×100) of liver sections (haematoxylin and eosin staining). IV Rat treated with yellow tea + NDEA. Pathological liver structure: (A) dysplastic nodule, (B) intrahepatic cholestasis and © extrahepatic cholestasis.

Figure 1. Representative images (×100) of liver sections (haematoxylin and eosin staining). I Control rat. Normal liver architecture. Representative images (×100) of liver sections (haematoxylin and eosin staining). II Rat treated with yellow tea alone. Normal liver structure. Representative images (×100) of liver sections (haematoxylin and eosin staining). III Rat treated with NDEA alone. Pathological liver structure: (A) dysplastic nodule or early hepatocellular carcinoma. Representative images (×100) of liver sections (haematoxylin and eosin staining). IV Rat treated with yellow tea + NDEA. Pathological liver structure: (A) dysplastic nodule, (B) intrahepatic cholestasis and © extrahepatic cholestasis.

Table 3. Effect of yellow tea extract on histopathological parameters in liver of rats given NDEA.

Figure 2. Fluorescence microscope-derived pictures of DNA damage in the liver of (A) control rats, (B) rats treated with yellow tea alone, (C) rats treated with NDEA alone and (D) rats treated with yellow tea + NDEA.

Figure 2. Fluorescence microscope-derived pictures of DNA damage in the liver of (A) control rats, (B) rats treated with yellow tea alone, (C) rats treated with NDEA alone and (D) rats treated with yellow tea + NDEA.

Table 4. Effect of yellow tea extract on lipid peroxidation (LPO), protein carbonyls (PCs) concentration, DNA damage and reduced glutathione (GSH) level in liver of rats given NDEA.

Table 5. Effect of yellow tea extract on hepatic antioxidant enzymes activity in rats given NDEA.

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