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Pharmaceutical Biology Volume 54, 2016 - Issue 10
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Research Article

Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model

Awodayo O. AdepitiDepartment of Pharmacognosy, Obafemi Awolowo University, Ile-Ife, Nigeria;
,
Anthony A. ElujobaDepartment of Pharmacognosy, Obafemi Awolowo University, Ile-Ife, Nigeria; Correspondence[email protected]
&
Oluseye O. BolajiDepartment of Pharmaceutical Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Pages 2298-2303 | Received 23 Feb 2015, Accepted 12 Feb 2016, Published online: 08 Apr 2016

Figures & data

Table 1. Average parasitaemia, chemosuppression and survival rate of CQ-sensitive P. berghei NK65-infected mice treated with single and combination doses of MAMA decoction and amodiaquine.

Table 2. Effects of single and combination doses of MAMA decoction and amodiaquine on the temperatures of CQ-sensitive P. berghei NK65-infected mice using the chemosuppressive and Rane tests.

Table 3. Effects of single and combination doses of MAMA Decoction and amodiaquine on CQ-resistant P. berghei ANKA-infected mice using the chemosuppressive test.

Figure 1. Effects of the combination of amodiaquine and MAMA decoction on CQ-sensitive P. berghei NK65-infected mice using the Rane test model.

Negative control (♦), MD 30 mg/kg (▴), AQ 1.25 mg/kg (□), MD 30 plus AQ1.25 mg/kg (×), AQ 10 mg/kg (•), MD 120 mg/kg (Δ), MD 120 plus AQ 10 mg/kg (+).

Figure 1. Effects of the combination of amodiaquine and MAMA decoction on CQ-sensitive P. berghei NK65-infected mice using the Rane test model.Negative control (♦), MD 30 mg/kg (▴), AQ 1.25 mg/kg (□), MD 30 plus AQ1.25 mg/kg (×), AQ 10 mg/kg (•), MD 120 mg/kg (Δ), MD 120 plus AQ 10 mg/kg (+).

Figure 2. Effects of the combination of amodiaquine and MAMA decoction on CQ-resistant P. berghei ANKA-infected mice using the Rane test model.

Negative control (□), AQ 10 mg/kg (•), MD 120 mg/kg (Δ), MD 240 mg/kg (▪), MD 480 mg/kg (⋄), MD120 plus AQ 10 mg/kg (▴), MD240 plus AQ10 mg/kg (×).

Figure 2. Effects of the combination of amodiaquine and MAMA decoction on CQ-resistant P. berghei ANKA-infected mice using the Rane test model.Negative control (□), AQ 10 mg/kg (•), MD 120 mg/kg (Δ), MD 240 mg/kg (▪), MD 480 mg/kg (⋄), MD120 plus AQ 10 mg/kg (▴), MD240 plus AQ10 mg/kg (×).

Table 4. Effects of single and combination doses of MAMA Decoction and amodiaquine on the temperatures of CQ-resistant P. berghei ANKA-infected mice.

Table 5. Survival rate of CQ-resistant P. berghei ANKA-infected mice treated with single and combination doses of MAMA Decoction and amodiaquine using the Rane test.

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