Association of thiol/disulfide ratio with syntax score in patients with NSTEMI

Figures & data

Table I. Baseline clinical and biochemical characteristics of the study population, and univariate analyses.

NSTEMI
Total (n = 290) (100%)		SXscore ≥ 23 (n = 96, 33%)	SXscore < 23 (n = 194, 67%)	p
Gender
Male n (%)	222 (76.6)	72 (75)	150 (77.3)	0.762
Female n (%)	68 (23.4)	24 (25)	44 (22.7)	0.715
Age Mean ± SD	61 ± 13	59 ± 14	62 ± 13	0.217
DM n (%)	72 (24.8)	26 (27)	46 (23.7)	0.283
Smoking n (%)	152 (52.4)	50 (52.08)	102 (52.5)	0.745
Free thiol (μmol/L)	228 ± 76	200 ± 78	242 ± 71	0.004*
Disulfide (μmol/L)	13.9 ± 6.5	14.1 ± 7.4	12.3 ± 5.4	0.065*
TDR Median (IQR)	15.4 (10.9–20.4)	10.6 (5.9–15.8)	18.1 (13.3–23.9)	< 0.001*
WBC count Mean ± SD (× 10^9/L)	11.2 ± 4.02	11.5 ± 4.47	11.1 ± 3.76	0.654
Hemoglobin Median (IQR) (g/L)	141 (126–155)	140 (121–152)	142 (130–160)	0.716
Neutrophil count Mean ± SD (× 10^9/L)	8.4 ± 3.8	8.4 ± 4.3	8.4 ± 3.5	0.830
Lymphocyte count Median (IQR) (× 10^9/L)	1.3 (1.0–1.6)	1.5 (1.1–2.4)	1.7 (1.0–2.4)	0.886
Platelet count Median (IQR) (× 10^9/L)	220 (190–257)	220 (181–255)	221 (193–258)	0.271
MPV Median (IQR) (fL)	10.6 (9.7–11.4)	10.5 (9.7–11)	10.6 (9.7–11.5)	0.851
Total cholesterol Mean ± SD (μmol/L)	4.99 ± 1.13	4.97 ± 1.11	4.99 ± 1.13	0.953
LDL Mean ± SD (μmol/L)	3.15 ± 1.01	3.13 ± 0.90	3.15 ± 1.06	0.894
HDL Mean ± SD (μmol/L)	1.06 ± 0.36	1.03 ± 0.28	1.06 ± 0.38	0.596
Peak Troponin I Median (IQR) (μg/L)	25 (5–51)	34 (4–50)	24 (6–47)	0.595
Creatinine Mean ± SD (μmol/L)	79.5 ± 6.2	85.7 ± 6.2	94.5 ± 7.9	0.322
Total Bilirubin Mean ± SD (μmol/L)	9.5 ± 5.1	9.4 ± 5.1	9.5 ± 5.1	0.573
LVEF (%) Mean ± SD	48 ± 11	42 ± 12	51 ± 9	< 0.001*
In hospital mortality n (%)	26 (8.9)	18 (18.7)	8 (4.1)	< 0.001*

NSTEMI, non-ST elevation myocardial infarction; DM, diabetes mellitus; HDL, high-density lipoprotein; IQR, interquartile range; LDL, low-density lipoprotein; LVEF, left ventricular ejection fraction; MPV, mean platelet volume; SD, standard deviation; TG, triglyceride; WBC, white blood cell.

*Statistacally significant.

Figure 1. Comparison of TDR in high and low SXscore groups. Logarithmic scale on y-axis. SXscore, Syntax score.

Figure 2. Correlation of TDR and SXscore s. SXscore, Syntax score.

Table II. Multivariate logistic regression analysis showing independent predictors of high SXscores.

			95% Confidence Interval
	P value	Β	Lower	Upper
TDR	< 0.001*	− 0.455	6.949	13.741
Free thiol (μmol/L)	0.053	− 0.153	13.860	70.111
disulfide (μmol/L)	0.076	0.122	10.856	45.036
LVEF (%)	0.001*	− 0.250	4.143	12.731

LVEF, Left Ventricular Ejection Fraction.

Figure 3. ROC analysis of TDRs in patients with high SXscores.

Table III. Clinical characteristics of the study population according to TDRs.

NSTEMI
	Total (n = 290) (100%)	TDR ≥ 14 (n = 170) (58.6%)	TDR < 14 (n = 120) (42.4%)	P value
Female n (%)	68 (23.4)	40 (23.5)	28 (23.3)	0.952
Age Mean ± SD	61 ± 13	59 ± 13	63 ± 14	0.043*
DM n (%)	72 (24.8)	43 (25.2)	29 (24.1)	0.879
WBC count Mean ± SD (× 10^9/L)	11.2 ± 4	11.0 ± 3.7	10.8 ± 3.7	0.743
Neutrophil count Mean ± SD (× 10^9/L)	8.4 ± 3.8	8.2 ± 3.7	8.5 ± 3.3	0.645
Platelet count Median (IQR)(× 10^9/L)	220 (190–257)	226 (194–254)	218 (199–251)	0.851
HDL Mean ± SD (μmol/L)	1.06 ± 0.36	1.08 ± 0.31	1.06 ± 0.46	0.849
Peak Troponin I Median (IQR) (μg/L)	25 (5–51)	18 (8–50)	23 (9–50)	0.045*
LVEF (%) Mean ± SD	48 ± 11	49 ± 10	45 ± 10	0.009*
In hospital mortality n (%)	26 (8.9)	6 (3.5)	20 (16.6)	< 0.001*
SXscore	18 ± 8	14 ± 6	22 ± 7	< 0.001*

NSTEMI, non-ST elevation myocardial infarction; DM, diabetes mellitus; HDL, high-density lipoprotein; IQR, interquartile range; SD, standard deviation; WBC, white blood cell.