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Modern Rheumatology Volume 28, 2018 - Issue 3
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Case report

Diffuse large B-cell lymphoma of the lacrimal sac arising from a patient with IgG4-related disease

Hidenori MarunakaDepartment of Otolaryngology, National Hospital Organization Okayama Medical Center, Okayama, Japan,
,
Yorihisa OritaDepartment of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Correspondence[email protected]
,
Tomoyasu TachibanaDepartment of Otolaryngology, Himeji Red Cross Hospital, Hyogo, Japan,
,
Kentaro MikiDepartment of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan,
,
Takuma MakinoDepartment of Otolaryngology, Himeji Red Cross Hospital, Hyogo, Japan,
,
Tadashi YoshinoDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, and
,
Kazunori NishizakiDepartment of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan,
&
Yasuharu SatoDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, and ;Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan
 show all
Pages 559-563 | Received 24 Aug 2015, Accepted 09 Dec 2015, Published online: 16 Feb 2016
 
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Abstract

A rare case of diffuse large B-cell lymphoma (DLBCL) possibly induced by IgG4-related disease is described. A 78-year-old woman was presented with a mass of the right lacrimal sac that extended to the inferior nasal meatus through the nasolacrimal duct. Pathological diagnosis was DLBCL with diffuse distribution of IgG4 + cells in the background of this lesion. The chronic inflammatory state of IgG4-related disease could have caused the development of DLBCL.

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