Pregnancy outcomes after exposure to tocilizumab: A retrospective analysis of 61 patients in Japan

Figures & data

Table 1. Patient demographics and characteristics,.

	Pregnancies, n (%) (N = 61)
Age, years
Mean (range)	30.5 (19–41)
10–19	2 (3.3)
20–29	16 (26.2)
30–39	23 (37.7)
40–49	1 (1.6)
Unknown	19 (31.1)
Indication for which tocilizumab was prescribed
Rheumatoid arthritis	53 (86.9)
Systemic juvenile idiopathic arthritis	1 (1.6)
Polyarticular juvenile idiopathic arthritis	0 (0.0)
Multicentric Castleman disease	2 (3.3)
Unknown	5 (8.2)
Route of tocilizumab administration
Intravenous infusion	56 (91.8)
Subcutaneous injection	4 (6.6)
Unknown	1 (1.6)
Timing of the last exposure to tocilizumab
Before last menstrual period	10 (16.4)
First trimester	30 (49.2)
Second trimester	0 (0)
Third trimester	0 (0)
Continued during pregnancy	2 (3.2)
Unknown	19 (31.1)

Table 2. Summary of abnormal neonatal outcomes.

Case	Concomitant use of methotrexate	Gestation age at birth, weeks	Birth weight (g)	Neonatal abnormality	Pregnancy period of last exposure to tocilizumab
1	No	38	2726	Neonatal asphyxia	First trimester
2	Yes	36	1650	Low birth weight/FGR	First trimester
3	Yes	36	1855	Low birth weight/FGR	First trimester
4	No	Unknown	1312	Low birth weight	First trimester (resumed during pregnancy^a)
5	No	Unknown	1402	Low birth weight/FGR	First trimester (resumed during pregnancy^a)
6	No	Unknown	<2000	Low birth weight	Continued during pregnancy

a Timing of resumption of tocilizumab was unknown.

FGR, fetal growth restriction.

Figure 1. Summary of birth event.

Table 3. Summary of spontaneous abortions.

Case	Age, years	Concomitant use of methotrexate	Pregnancy period of last exposure to tocilizumab	Gestation age at abortion, weeks
1	31	Yes	First trimester	First trimester
2	34	Yes	First trimester	First trimester
3	35	Yes	First trimester	First trimester
4	29	Yes	Discontinued before last menstrual period	First trimester
5	37	No	Discontinued before last menstrual period	First trimester
6	33	No	Unknown	First trimester
7	Unknown	No	Unknown	Unknown
8	32	No	First trimester	First trimester
9	28	Yes	Unknown	Unknown