Synthesis and leishmanicidal activity of 2,3,4-substituted-5-imidazolones

Figures & data

Figure 1.  Structure of compound 5.

Scheme 1.  Synthesis of imidazolones 1–29.

Table 1.  Results for anti-leishmanial activity of compounds 1–29.

Compound	IC50 ± SEM^a (μg/mL)	Compound	IC50 ± SEM^a (μg/mL)
1	64.12 ± 0.21	16	>100
2	75.08 ± 0.05	17	12.98 ± 0.32
3	67.16 ± 0.31	18	57.30 ± 0.04
4	>100	19	51.00 ± 0.03
5	77.70 ± 0.11	20	63.24 ± 0.24
6	75.00 ± 0.24	21	51.32 ± 0.33
7	>100	22	78.34 ± 0.55
8	>100	23	61.43 ± 0.31
9	57.00 ± 0.21	24	41.12 ± 0.32
10	>100	25	96.17 ± 0.11
11	80.00 ± 0.23	26	72.30 ± 0.23
12	84.80 ± 0.25	27	>100
13	60.00 ± 0.13	28	65.39 ± 0.12
14	28.20 ± 0.03	29	77.92 ± 0.21
15	54.44 ± 0.05
Amphotericin B^b	0.12 ± 0.41	Pentamidine^c	2.56 ± 0.10

^aSEM is the standard error of the mean.

^bAmphotericin B and

^cpentamidine are standard drugs for leishmanicidal activity.