In vitro inhibition of polyphenol oxidase by some new diarylureas

Figures & data

	X	R1	R2	R3	R4	R5
1	O	-H	-H	-CH3	-H	-H
2	S	-H	-H	-CH3	-H	-H
3	S	-H	-H	-NO2	-H	-H
4	O	-H	-H	-F	-H	-H
5	S	-H	-I	-H	-H	-H
6	S	-H	-F	-H	-H	-H
7	S	-F	-H	-H	-H	-H
8	S	-H	-CF3	-H	-H	-H
9	S	-H	-Cl	-H	-Cl	-H

Figure 1.  K_i graphics of diarylureas on BPPO.

Table 1.  The K_i values of diarylureas on BPPO.

Diarylureas	Ki (mM)	Inhibition type
1	0.285	Competitive
2	17.97	Non-competitive
3	0.187	Competitive
4	–	–
5	0.108	Competitive
6	0.063	Competitive
7	0.044	Competitive
8	0.047	Competitive
9	–	–