Figures & data
Scheme 1. Synthesis of novel bromophenols (i) PPA, 80°C, 85%; (ii) 1.2 eq Br2/CH2Cl2, 25°C, 47%; (iii) 4 eq Br2/CH2Cl2, 25°C; (iv) 1. BBr3/CH2Cl2, 0–25°C, 2. MeOH or H2O, 0–25°C.
![Scheme 1. Synthesis of novel bromophenols (i) PPA, 80°C, 85%; (ii) 1.2 eq Br2/CH2Cl2, 25°C, 47%; (iii) 4 eq Br2/CH2Cl2, 25°C; (iv) 1. BBr3/CH2Cl2, 0–25°C, 2. MeOH or H2O, 0–25°C.](/cms/asset/ecbdb7c4-8b00-4ee5-863c-276c358432c1/ienz_a_715287_f0002_b.gif)
Table 1 Purification steps of PON1 enzyme from human serum by Ammonium sulfate precipitation, anion exchange chromatography and gel filtration chromatography.
Table 2. IC50 values of chemicals on PON1.