Scheme 1. Synthetic path of the target compounds.
Figure 1. Dose-dependent inhibitory effect of the compounds 3b, 3c, 5a and 6a. Orlistat was used positive control. All compounds and Orlistat were measured at final concentrations of 0.625, 1.25 and 6.25 µg/mL. Residual activities of compounds are expressed as the mean ± SD in triplicate.
Table 1. Residual lipase activity of chemical compounds.
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