Figures & data
Figure 1. Chemical structure of active chemotherapeutic Diuretic and antihypertensive agents (Metolazone and Prazosin, Diazoxide) and rationally designed template for targeted compound (20).
![Figure 1. Chemical structure of active chemotherapeutic Diuretic and antihypertensive agents (Metolazone and Prazosin, Diazoxide) and rationally designed template for targeted compound (20).](/cms/asset/e74e1323-605b-40d9-8a05-60bcdbee8aeb/ienz_a_845820_f0001_b.jpg)
Scheme 1. Synthesis of N-(substituted-4-oxo-2-substituted-phenylquinazolin-3-(4H)-yl)substituted benzenesulfonamide derivatives.
![Scheme 1. Synthesis of N-(substituted-4-oxo-2-substituted-phenylquinazolin-3-(4H)-yl)substituted benzenesulfonamide derivatives.](/cms/asset/869b5a89-7a08-4b5d-91c2-33539e2a7238/ienz_a_845820_f0002_b.jpg)
Table 1. Diuretic activity data shown by compounds 1–25.
Table 2. Diuretic activity data shown by some active compound.
Figure 2. Graph showing decrease in the systolic blood pressure (SBP) exhibited by compounds (1–25) and standard as compared to control.
![Figure 2. Graph showing decrease in the systolic blood pressure (SBP) exhibited by compounds (1–25) and standard as compared to control.](/cms/asset/06aaf460-f0ad-4d5f-a8d0-22dcf3c48a59/ienz_a_845820_f0003_b.jpg)
Table 3. Antihypertensive activity data shown by compounds 1–25.
Figure 3. Graph showing changing in blood glucose concentration exhibited by some potent compounds and compared with diazoxide.
![Figure 3. Graph showing changing in blood glucose concentration exhibited by some potent compounds and compared with diazoxide.](/cms/asset/a8cec1fa-dbd5-4941-8bd0-aade8ecf6252/ienz_a_845820_f0004_b.jpg)
Table 4. Evaluation of anti-diabetic potential.