Figures & data
Scheme 1. Reagents and reaction conditions: (i) HNO3, H2SO4, rt, 4 h; (ii) NaOtBu, DMF, rt, 4 h; (iii) 5% Pd/C, H2, MeOH, rt, 1 h; (iv) Pd(OAc)2, BINAP, CsCO3, toluene, reflux, 6 h.
![Scheme 1. Reagents and reaction conditions: (i) HNO3, H2SO4, rt, 4 h; (ii) NaOtBu, DMF, rt, 4 h; (iii) 5% Pd/C, H2, MeOH, rt, 1 h; (iv) Pd(OAc)2, BINAP, CsCO3, toluene, reflux, 6 h.](/cms/asset/71c9d732-5446-42d3-9604-19e971621c7f/ienz_a_958082_sch0001_c.jpg)
Scheme 2. Reagents and reaction conditions: (i) formamidine acetate, HCONH2, 160 °C, 12 h; (ii) N-bromosuccinimide, AIBN, CCl4, rt, 24 h; (iii) POCl3, N,N-dimethylaniline, toluene, reflux, 4 h; (iv) methylamine, THF, rt, 12 h; (v) NaOtBu, DMF, rt, 4 h.
![Scheme 2. Reagents and reaction conditions: (i) formamidine acetate, HCONH2, 160 °C, 12 h; (ii) N-bromosuccinimide, AIBN, CCl4, rt, 24 h; (iii) POCl3, N,N-dimethylaniline, toluene, reflux, 4 h; (iv) methylamine, THF, rt, 12 h; (v) NaOtBu, DMF, rt, 4 h.](/cms/asset/5282ec88-bfb2-47c5-afe1-17804b9aa846/ienz_a_958082_sch0002_c.jpg)