Figures & data
Table 1. Antibacterial inhibition zone in mm ± standard deviation and minimal inhibitory concentrations (MIC, µg/mL, between brackets) of some newly synthesized compounds.
Table 2. Antifungal inhibition zone in mm ± standard deviation and minimal inhibitory concentrations (MIC, µg/mL, between brackets) of some newly synthesized compounds.
Figure 2. Predicted binding modes of the studied compounds generated by MOE-Dock. (A) Interactions with key residues in the crystal structure of the STZ-DHPP adduct (orange carbons) with BaDHPS (PDB code 3TYE, STZ: sulfathiazole, DHPP: 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate). (B–F) Docking poses for compounds 7a, 9b, 9e, 10a and 10e, respectively (green: ligand's carbon, red: oxygen, blue: nitrogen, yellow: sulfur, white: hydrogen). Protein is shown as light gray cartoons, hydrogen bonds as dotted red lines, and crystal water W286 as magenta sphere. Colors are available in the online version of the paper.
![Figure 2. Predicted binding modes of the studied compounds generated by MOE-Dock. (A) Interactions with key residues in the crystal structure of the STZ-DHPP adduct (orange carbons) with BaDHPS (PDB code 3TYE, STZ: sulfathiazole, DHPP: 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate). (B–F) Docking poses for compounds 7a, 9b, 9e, 10a and 10e, respectively (green: ligand's carbon, red: oxygen, blue: nitrogen, yellow: sulfur, white: hydrogen). Protein is shown as light gray cartoons, hydrogen bonds as dotted red lines, and crystal water W286 as magenta sphere. Colors are available in the online version of the paper.](/cms/asset/084fdd10-c2c6-4f54-af45-59b0fbbd1241/ienz_a_1016514_f0002_c.jpg)