Figures & data
Figure 1. Synthetic procedures for the synthesis of chalcones a1–a4, of diether c and of bis-chalcones ethers b1–b4.
![Figure 1. Synthetic procedures for the synthesis of chalcones a1–a4, of diether c and of bis-chalcones ethers b1–b4.](/cms/asset/1de0dfed-1d99-401a-a1b0-b1b893af38a1/ienz_a_1021253_f0001_b.jpg)
Figure 2. (A) 4-Hydroxy-substituted chalcones a (1–4). (B) Bis-chalcones etherified derivatives b (1–4).
![Figure 2. (A) 4-Hydroxy-substituted chalcones a (1–4). (B) Bis-chalcones etherified derivatives b (1–4).](/cms/asset/1981c917-2d82-4bac-8199-5fb4cd31b73c/ienz_a_1021253_f0002_b.jpg)
Table 1. Lipophilicity values: (i) theoretically calculated as clog P and (ii) experimentally determined as RM.
Table 2. Interaction–RA% with DPPH (RA%); % inhibition of lipid peroxidation (AAPH%); in vitro inhibition of soybean LOX (IC50 or %); in vitro inhibition of AChE (IC50 or %).
Table 3. Physicochemical properties calculated by the program Spartan v. 5.1.3.
Figure 3. Inhibition % of AChE induced by100 μM of compounds a3, b (2–4) in relation to the time (0–30 min).
![Figure 3. Inhibition % of AChE induced by100 μM of compounds a3, b (2–4) in relation to the time (0–30 min).](/cms/asset/3c4fa6b7-b8c2-4f63-9437-0a6bb5470f41/ienz_a_1021253_f0003_c.jpg)
Table 4. Stability studies and incubation with GSH.
Figure 4. Cytotoxicity of chalcones (a1–a4) and Bis-chalcones–ethers (b1–b4) on L929 cells (24-h incubation) expressed as PI % values.
![Figure 4. Cytotoxicity of chalcones (a1–a4) and Bis-chalcones–ethers (b1–b4) on L929 cells (24-h incubation) expressed as PI % values.](/cms/asset/55eb4085-45dd-4362-9a57-b1ac3eab3dd9/ienz_a_1021253_f0004_c.jpg)