1,314
Views
4
CrossRef citations to date
0
Altmetric
Original Article

Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1

, , , , &
Pages 34-39 | Received 23 Dec 2015, Accepted 01 Mar 2016, Published online: 01 Apr 2016

Figures & data

Scheme 1. Formation of 4-aminoquinazolines 2–15.

Scheme 1. Formation of 4-aminoquinazolines 2–15.

Figure 1. Dose-response curves for NQO1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives. Data are expressed as the ratio of treated/control (T/C) values.

Figure 1. Dose-response curves for NQO1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives. Data are expressed as the ratio of treated/control (T/C) values.

Table 1. NQO1 inducer potency of novel 2-phenylquinazolin-4-amine derivatives.

Figure 2. Interaction map of the native ligand in the Kelch domain of Keap 1 (PDB ID: 41QK).

Figure 2. Interaction map of the native ligand in the Kelch domain of Keap 1 (PDB ID: 41QK).

Figure 3. Interaction map of compound 12 in the Kelch domain of Keap 1 (PDB ID: 41QK).

Figure 3. Interaction map of compound 12 in the Kelch domain of Keap 1 (PDB ID: 41QK).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.