Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats

Figures & data

Figure 1. (A) The effects of ischemia/reperfusion (I/R) and treatment with Naringin on the MDA levels. *Between the I/R and control, I/R + NAR, p < 0.01. (B) The effects of ischemia/reperfusion (I/R) and treatment with Naringin on the GSH-Px levels. *Between the I/R and control, I/R + NAR, p < 0.05. (C) The effects of ischemia/reperfusion (I/R) and treatment with Naringin on the SOD levels. *Between the control and I/R and I/R + NAR, p < 0.01, **Between the I/R and I/R + NAR, p < 0.01. (D) The effects of ischemia/reperfusion (I/R) and treatment with Naringin eon the CAT levels. *Between the control and I/R, I/R + NAR, p < 0.05, **Between the I/R and I/R + NAR, p < 0.05.

Figure 2. (A) Creatine kinase levels. *Between the control and I/R, I/R + NAR, p < 0.01, **Between the I/R and I/R + NAR, p < 0.05. (B) Lactate dehydrogenase (LDH) as indicators of muscle damage in blood levels of all groups. (C) Leukocyte infiltration of the all groups (the average leukocyte counts/0.25 mm²). *Between the control and I/R, p < 0.05, **Between the I/R and I/R + NAR, p < 0.05.

Table 1. Comparison of the effects of ischemia/reperfusion (I/R) on the histological evaluation scores of the each group.

Histological parameters	Control	I/R	I/R + NAR
Deterioration in epimysium	-	+++	++
Deterioration in perimysium	-	+++	++
Increased cellularity in perimysium	-	+++	++
Degeneration in the arterial wall	-	+++	++
Vasodilatation	-	+++	+
Coagulation in vessels	-	++	-

-, Grade 0/normal; +, Grade 1; ++, Grade 2; +++, Grade 3.