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Original Article

High tissue factor activity and low tissue factor pathway inhibitor concentrations in patients with preterm labor

, , , , , , , , , , , , , , & show all
Pages 23-33 | Received 23 Feb 2009, Accepted 21 Apr 2009, Published online: 03 Nov 2009

Figures & data

Table I.  Demographic and clinical characteristics of the study population.

Table II.  Prevalence of intra-amniotic microorganisms in patients with PTL that underwent diagnostic amniocentesis (n = 16).

Figure 1.  (a) Maternal TF (TIL: median 432.8 pg/ml, range 130.1–1043.7 vs. TNL: median 320.7 pg/ml, range 70.5–1415.2): (b) TFPI (TIL: median 56.6 ng/ml; range 30–87.7, vs. TNL: median 65.3 ng/ml, range 45.5–117.8), and plasma concentrations and (c) the TFPI/ TF ratio (TNL: median 201.4, range 40.1–1326.2 vs. TIL: median 126.2, range 48.3–457.3) between women with and without spontaneous labor at term.

Figure 1.  (a) Maternal TF (TIL: median 432.8 pg/ml, range 130.1–1043.7 vs. TNL: median 320.7 pg/ml, range 70.5–1415.2): (b) TFPI (TIL: median 56.6 ng/ml; range 30–87.7, vs. TNL: median 65.3 ng/ml, range 45.5–117.8), and plasma concentrations and (c) the TFPI/ TF ratio (TNL: median 201.4, range 40.1–1326.2 vs. TIL: median 126.2, range 48.3–457.3) between women with and without spontaneous labor at term.

Figure 2.  Maternal plasma TF concentration in women with a normal pregnancy and patients with PTL according to the presence of intra-amniotic infection/inflammation and those who delivered at term. (Normal pregnancy median 291.5 pg/ml; range 6.3–2662.2; PTL who delivered at term: median 258.6 pg/ml, range 65.9–1495.3; PTL who delivered preterm without IAI: median 272.97 pg/ml, range 33.5–1774.6; PTL who delivered preterm with IAI: median 345.7 pg/ml, range 98.5–1237.0).

Figure 2.  Maternal plasma TF concentration in women with a normal pregnancy and patients with PTL according to the presence of intra-amniotic infection/inflammation and those who delivered at term. (Normal pregnancy median 291.5 pg/ml; range 6.3–2662.2; PTL who delivered at term: median 258.6 pg/ml, range 65.9–1495.3; PTL who delivered preterm without IAI: median 272.97 pg/ml, range 33.5–1774.6; PTL who delivered preterm with IAI: median 345.7 pg/ml, range 98.5–1237.0).

Figure 3.  Maternal plasma TFPI concentrations in women with normal pregnancy and patients with PTL according to the presence of intra-amniotic infection/inflammation and those who delivered at term. (Normal pregnancy median 66.1 ng/ml; range 14.3–86.5; PTL who delivered at term: median 54.7 ng/ml, range 28.6–96; PTL who delivered preterm without IAI: median 56.7 ng/ml, range 30.3–78.5; PTL who delivered preterm with IAI: median 55.2 ng/ml, range 34.7–96.7).

Figure 3.  Maternal plasma TFPI concentrations in women with normal pregnancy and patients with PTL according to the presence of intra-amniotic infection/inflammation and those who delivered at term. (Normal pregnancy median 66.1 ng/ml; range 14.3–86.5; PTL who delivered at term: median 54.7 ng/ml, range 28.6–96; PTL who delivered preterm without IAI: median 56.7 ng/ml, range 30.3–78.5; PTL who delivered preterm with IAI: median 55.2 ng/ml, range 34.7–96.7).

Table III.  Multiple logistic regression analysis of the association of maternal plasma TF concentrations and activity as well as TFPI and activity and preterm labor.

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